MICAD eAnnouncement
(January, 2012)

     The mission of the Molecular Imaging and Contrast Agent Database (MICAD) program is to foster research and development in molecular imaging by providing free online scientific information regarding in vivo molecular imaging and contrast agents to individuals working in the field. This eAnnouncement provides News associated with MICAD and lists the Agents that have been uploaded recently to MICAD.

I. MICAD News
1.      A total of 1151 imaging agents are now available in MICAD.

2.      Molecular Imaging Probes & Contrast Agents List: ~4820 imaging agents with in vivo studies are now available (updated, 11/7/2011).
These agents have been published in peer-reviewed journals from 1970 to October, 2011. Download the list.

3.      FDA-Approved Contrast Agents List (updated, 11/7/2011). Download the list.

4.      A summary of all MICAD entries can be downloaded as a CSV file from the MICAD homepage. Download the list (updated, 2/2/2012).

5.      Agent search function. Agents can be searched on the basis of the method of detection, sources of signal, agent category, target category, or text words.

6.      New publications:
1)      Important parameters to consider for the characterization of PET and SPECT imaging probes.
        Chopra, A., Shan, L., Eckelman, W. C., Leung, K. and Menkens, A.
       Nucl Med Biol 2011, 38(8):1079-1084

2)      Molecular imaging and contrast agent database (MICAD): Evolution and progress.
        Chopra, A., Shan, L., Eckelman, W. C., Leung, K., Latterner, M., Bryant, S. and Menkens, A.
       Mol Imaging Biol 2012, 14(1):4-13

II. The MICAD Guest Author Program
       Members of the imaging community are invited to contribute to the MICAD database by writing and submitting chapters on agents of their interest for online publication. For more information, please visit our website: www.micad.nih.gov.

Newly Uploaded Agents in January (24 agents)

PET
·         [18F]4-FGln  — Amino acid transporter
·         [18F]RP1005  — Mitochondrial complex I (MCI)
·         [18F]RP1003  — Mitochondrial complex I (MCI)
·         [18F]10  — Mitochondrial complex I (MCI)
·         BMS-747158-02  — Mitochondrial complex I (MCI)
·         [18F]FESP — D2 dopamine receptor and 5-HT2 serotonin receptor
·         18F-FBO- (ZHER2:477)2 — HER2
·         18F-FBO-ZHER2:477 — HER2
·         18F-FBO-MUT-DS  — HER2
·         68Ga-DOTA-MUT-DS — HER2
·         89Zr-Fresolimumab  — Transforming growth factor-β (TGF-β)
·         89Zr-Df-TRC105  — CD105 (Endoglin, EDG)
·         64Cu-DOTA-TRC105  — CD105 (Endoglin, EDG)
·         64Cu-AMD3465  — Chemokine receptor 4 (CXCR4)
·         [11C]SCH 23390  — Dopamine D1 receptor

Optical Imaging
·  FANPs  — Matrix metalloproteinases (MMPs)
·  PAM78  — Hydroxyapatite
·  E4X12-VT750  — Glucagon-like peptide-1 receptor (GLP-1R)
SPECT
·  111In-DTPA-Ahx-Lys40-exendin-4  — Glucagon-like peptide-1 (GLP-1) receptor
·  99mTc-HYNIC-EGF  — Epidermal growth factor receptor (EGFR)
Multimodal Imaging
·  111In-A5-CCPM  — Phosphatidylserine, apoptosis
·  111In-TNYL-RAW-CCPM  — Ephrin receptor B4 (EphB4)
MRI
·  Yb-DO3A-oAA  — Non-targeted
Ultrasound
·  MBE  — Integrin αvβ3

The MICAD Team
NCBI/NLM/NIH