Monday, May 27 ISRS 2019 Program Schedule

08:30 KEYNOTE LECTURE 2

Session Chair: Fan Wang

O-02 Clinical translation of molecular imaging in nuclear medicine: PUMCH experience
Fang Li, Peking Union Medical College Hospital

09:15 RADIOLABELED COMPOUNDS - ONCOLOGY (IMAGING) SESSION 1

Session Chairs: Yuji Kuge | Irina Velikyan

O-03 Bispecific anti-GRPR/PSMA heterodimer for PET and SPECT imaging diagnostic of prostate cancer
Anna Orlova, Uppsala University

O-04 Pretargeted tumor imaging with 64Cu-labeled ultrastable cross-bridged macrocyclic complex
Abhinav Bhise, Kyungpook National University

O-05 Targeting CD206+ Tumor-Associated Macrophages using a Finely Tuned Albumin Nano-platform for Earlier Detection of Breast Cancer Metastases
Ji Yong Park, Seoul National University, College of Medicine

O-06 Improving Pharmacokinetics of 99mTc-ref with PEG Linkers for HER2-Targeted SPECT Imaging of Breast Cancer
Shuaifan Du, Peking University

10:15 COFFEE BREAK 1, 5/27

11:00 RADIOCHEMISTRY - 18F SESSION 1

Session Chairs: Byung Chul Lee | Jennifer Murphy

O-07 Generation of 18F-metal fluorides from [18F]HF generated by acidic QMA elution and application towards 18F-fluorination/ring-opening of complex epoxides
Stefan Verhoog, Merck & Co inc.

O-08 Pretargeted PET imaging using a dual click 18F-labeling strategy
Johanna Steen, Department of Drug Design and Pharmacology, University of Copenhagen

O-09 Development of highly affine 18F-labelled radiotracers for PET imaging of the adenosine A2A receptor
Thu Hang Lai, Helmholtz-Zentrum Dresden-Rossendorf

O-10 Preparation of [18F]fluoroalkenyliodonium salts and their application for radiolabeling by cross coupling reactions
Swen Humpert, Forschungszentrum Jülich GmbH

O-11 High molar activity [18F]trifluoromethane for PET tracer synthesis
Anna Pees, Amsterdam UMC, VU University

O-12 Synthesis and evaluation of [18F]canagliflozin for imaging SGLT-2-transporters in diabetic patients.
Philip Elsinga, University Medical Center Groningen

12:30 LUNCH 5/27

14:00 MULTIMODALITY IMAGING PROBES / NANOPARTICLES

Session Chairs: Xiaoyuan Chen | Mikako Ogawa

O-13 Magnetic Nanotheranostics Enhances Cerenkov Radiation-Induced Photodynamic Therapy
Dalong Ni, University of Wisconsin

O-14 Bimodal PSMA ligands for intra-operative tumor detection and targeted photodynamic therapy of PSMA-expressing tumors
Peter Laverman, Radboud University Medical Center

O-15 Evaluation of N-alkylaminoferrocenes for in‐vivo imaging of reactive oxygen species activity using PET and optical imaging
Johannes Toms, Friedrich-Alexander University Erlangen-Nürnberg (FAU), Department of Nuclear Medicine, Molecular Imaging and Radiochemistry

O-16 A Cell Surface Thiol Targeting Dual PET and Fluorescent Labelling Reagent for Multi-Scale Cell Tracking
Truc Pham, King's College London

15:00 COFFEE BREAK 2, 5/27

15:45 RAPID FIRE POSTER 1

P-051 Late stage 18F-difluoromethylation via a flow photoredox reaction to N-heteroaromatics.
Laura Trump, Global Chemistry,UCB New medicines, UCB Biopharma sprl

P-113 H2CHXhox, Cyclohexane Reinforced Chelating Ligand for Ga3+ and Cu2+
Xiaozhu Wang, University of British Columbia

P-280 New, potent PSMA-inhibitors using squaric acid for coupling and increased affinity
Lukas Greifenstein, Johannes Gutenberg University Mainz, Institute of Nuclear Chemistry

P-341 [89Zr]ZrDFO-CR011 PET Imaging to Predict Response to an Antibody Drug Conjugate for gpNMB in Triple Negative Breast Cancer
Supum Lee, Yale School of Medicine

P-205 Development and preclinical evaluation of intrinsically radiolabeled [103Pd]AuPd nanoparticles in an injectable seed-forming system for nanobrachytherapy
Matthias Fach, DTU Nanotech

P-061 Synthesis and preliminary preclinical evaluation of a 18F-fluorinated quaternary α-amino acid-based arginase inhibitor
Goncalo Clemente, University Medical Center Groningen

P-116 Synthesis of novel 99mTc tricarbonyl-HBED-CC complexes and structural prediction in solution by density functional theory calculation
Shengyu Shi, College of Chemistry, Beijing Normal University

P-295 Site-specifically radiolabelled Human PD-L1 Nanobody: a new tool for clinical PET imaging
Jessica Bridoux, In Vivo Cellular and Molecular Imaging (ICMI), Vrije Universiteit Brussel (VUB)

P-350 Preclinical evaluation of chemokine receptor 4 (CXCR4) as a theranostic target in high-risk neuroblastoma
Dijie Liu, University of Iowa

P-128 Evaluation of a new dicarboxy-monoamide-tetraaza-bifunctional chelator for rapid room temperature labeling of lead and copper radionuclides for radiopharmaceuticals.
Edwin Sagastume, Viewpoint Molecular Targeting, Inc.

P-353 Optimization of 177Lu-labeled GRPR-antagonist PEG2-RM26 for GRPR-targeted radiotherapy: influence of chelator on labeling, stability and biodistribution
Bogdan Mitran, Uppsala University

P-310 89Zr-immuno-PET and biodistribution preclinical studies to compare the tumor targeting of the novel anti-CD166 Probody Drug Conjugate CX-2009 and its parental derivatives in a lung cancer xenograft mouse model.
Marion Chomet, Amsterdam UMC, VU University, Radiology and Nuclear Medicine

16:00 RADIOCHEMISTRY - RADIOMETALS

Session Chairs: Carolyn Anderson | Jiyun Shi

O-17 Towards cancer theranostics: 68Ga-, 44gSc-, 177Lu- and 225Ac-labeled bombesin derivatives.
Simon Ferguson, University of Alberta

O-18 Synthesis and comparison of novel fusarinine C-based chelators for 89Zr-labeling
Chuangyan Zhai, Southern Medical University

O-19 New Bifunctional Chelators for Theranostic Applications
Lee Lee Lily Li, The University of British Columbia

O-20 Cooperative capture synthesis for the development of novel supramolecular radiotracers
Faustine d'Orchymont, University of Zurich

O-21 In vivo stable Bisarylmercury Bispidine as a Tool for Hg-197(m) Applications
Ian Moore Gilpin, HZDR

O-22 Positron emission tomography imaging of adeno-associated virus serotype 9-tetracystein (AAV9-TC) labeled with a multichelator
Jai Woong Seo, Stanford University

17:30 POSTER SESSION 1A: RADIOCHEMISTRY - 18F

P-001 Synthesis and initial in vitro characterization of [18F]fluoroalkyl derivatives of GSK1482160 as new candidate P2X7R radioligands
Qi-Huang Zheng, Indiana University School of Medicine

P-006 Radiosynthesis of [18F]FEDAC with the hydrous 18F-fluorination using Kryptofix 222 and potassium carbonate.
Kazunori Kawamura, National Institute of Radiological Sciences, National Institute for Quantum and Radiological Science and Technology

P-011 Design of a new 18F-prosthetic reagent for the “thiol-ene”-Dha-based conjugation with proteins
Mylène Richard, Imagerie Moléculaire In Vivo UMR1023 CEA, INSERM, CNRS, Université Paris Sud, Université Paris-Saclay, Service Hospitalier Frédéric Joliot

P-016 Radiosynthesis of [18F]Fluoroaminoesters by Deoxyradiofluorination of b-Hydroxy-a-aminoesters under mild conditions
Cecile Perrio, Cyceron

P-021 Automated radiosynthesis of 2-[18F]BTSO2CF2H in a GE FASTLab synthesizer
Agostinho Lemos, University of Liège

P-026 Ruthenium-mediated 18F-fluorination of phenols at Turku PET Centre
Noora Rajala, Turku PET Centre, University of Turku

P-031 Synthesis of 18F-labelled fragmented antibody [18F]Fab
Olli Eskola, University of Turku, Turku PET Centre

P-036 Novel Pyridinyl Quarternary Ammonium Salts as Precursors of Radiofluorination
Murthy Akula, University of Tennessee Medical center

P-041 Aromatic [18F]fluorination of [18F]BS224 and its bioevaluation in animal models of neuroinflammation and stroke
Sang Hee Lee, Department of Transdisciplinary Studies, Graduate School of Convergence Science and Technology, Seoul National University

P-046 One step synthesis of N-succidimidyl-4-[18F]-fluorobenzoate ([18F]SFB)
Ida Petersen, Department of Clinical Physiology, Nuclear Medicine and PET, University Hospital Copenhagen

P-051 Late stage 18F-difluoromethylation via a flow photoredox reaction to N-heteroaromatics.
Laura Trump, Global Chemistry,UCB New medicines, UCB Biopharma sprl

P-056 Radiosynthesis of 18F-Crizotinib, a potential radiotracer for PET imaging of the P-glycoprotein transport function at the blood-brain barrier
Malvika Sardana, Early Chemical Development, Pharmaceutical Sciences, IMED Biotech Unit, AstraZeneca, Gothenburg, Sweden

P-061 Synthesis and preliminary preclinical evaluation of a 18F-fluorinated quaternary α-amino acid-based arginase inhibitor
Goncalo Clemente, University Medical Center Groningen

P-066 A Combinatorial Library of Fluorine-Integrated Peptides for PET Imaging Agent Discovery
Emily Murrell, University of Western Ontario

P-071 Automated production of high specific activity [18F]6F-l-DOPA using a TRACERLab FXFN synthesis module
Peter Scott, The University of Michigan

P-076 18F- PEG2-OTSSP167 inhibits maternal embryo leucine zipper kinase for PET imaging of triple-negative breast cancer
Hu Jia, Department of Nuclear Medicine, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology

17:30 POSTER SESSION 1A: RADIOCHEMISTRY - RADIOMETALS

P-104 Bispidine Chelators for Radiometals
Miriam Starke, Heidelberg University

P-107 Perfluorinated Calixarene Shuttles for Radium and Barium
Falco Reissig, Helmholtz-Zentrum Dresden-Rossendorf

P-110 Preparation and preliminary evaluation of 68Ga labeled PSMA inhibitor [68Ga]-NOTA-ANCP-PSMA
Kai Wen, China Isotope & Radiation Corporation

P-113 H2CHXhox, Cyclohexane Reinforced Chelating Ligand for Ga3+ and Cu2+
Xiaozhu Wang, University of British Columbia

P-116 Synthesis of novel 99mTc tricarbonyl-HBED-CC complexes and structural prediction in solution by density functional theory calculation
Shengyu Shi, Collage of Chemistry, Beijing Normal University

P-119 New trans-[M(SS)(isc)2(CO)2], [M(SS)(P)2(CO)2] and [M(SS)(isc)(P)(CO)2], (M=99mTc/Re) mixed ligand complexes
Myrto Ischyropoulou, NCSR Demokritos

P-122 Investigation of intramolecular complexes of hydroxyalkylamines for chelation of 68Ga with PSMA-HBED-CC.
Dmitrii Antuganov, Almazov National Medical Research Centre

P-125 Production of [62Zn]Citrate and [62Cu]Glycine with a modified 62Zn/62Cu generator system.
Zilin Yu, King's College London

P-131 A novel FAP-inhibitor containing squaric acid coupled DOTA: Synthesis and preliminary evaluation
Elisabeth Eppard, PositronPharma

P-134 89Zr Solutions: Preparation, Formulation, Analysis and Comparison of Applicability for Radiopharmaceutical Purposes
Anton Larenkov, State Research Center - Burnasyan Federal Medical Biophysical Center

P-137 Synthesis and Biological Evaluation of Tz-PEG4-HBEDCC-68Ga Confirming its Capability for Bioorthogonal and Pretargeted Imaging
Elisavet Lambidis, University of Helsinki

P-140 Tripodal N-centred Phosphine Ligands: Towards a Novel Donor Set for 99mTc and 186/188Re Radiopharmaceutical Formulation
Saul Cooper, Imperial College London

P-143 Characterization of Yttrium Hydroxycarbonate Microparticles for [90Y]Y-Based Liquid Brachytherapy Agent Development
Anster Charles, University of Missouri Department of Chemistry

P-146 Automated production and purification of Copper medical radioisotopes in a variable energy cyclotron using solid targets
Dana Niculae, Horia Hulubei National Institute for Physics and Nuclear Engineering

P-149 Clinical implementation of cyclotron-based [68Ga]Ga-PSMA-11 at the University of Michigan
Peter Scott, The University of Michigan

P-152 Pre-targeted glucose metabolism imaging of murine tumors with 99mTc labelled dibenzocyclooctyne derivative
Taiwei Chu, Peking University

17:30 POSTER SESSION 1A: RADIOCHEMISTRY - OTHER RADIONUCLIDES

P-155 Synthesis of 4-(4-[I-123]Iodophenyl)piracetam, a Potential SPECT Agent for Parkinson’s Disease.
Murthy Akula, University of Tennessee Medcial center

P-157 Production, formulation and quality control of [13N]NH3 for clinical use.
Pardeep kumar, NIMHANS

P-159 Direct nucleophilic radioiodination and astatination of antibodies via pre-conjugated arylboronic acids
Francois Guérard, Université de Nantes, CRCINA, Nuclear Oncology Group

17:30 POSTER SESSION 1A: AUTOMATION / MICROFLUIDICS / PROCESS DEVELOPMENT

P-163 Facile two-step one-pot automated radiosynthesis of [18F]FET suitable for clinical PET study of brain tumors
Min Wang, Indiana University School of Medicine

P-167 Spirocyclic Iodonium Ylide (SCIDY)-Mediated Automatic Radiolabeling of [18F]FDPA and Validation for Human Use
Lu Wang, The first affiliated hospital of Jinan University

P-171 Click chemistry on TracerLab: towards GMP manufacturing of high molar activity 18F PET tracers
Federica Pisaneschi, UT MD Anderson Cancer Center

P-175 Simple and fully automatic production of [18F]fluorodeprenyl-D2 using FXFN chemistry module
Miran Kim, Department of Nuclear Medicine, Asan Medical Center, University of Ulsan College of Medicine

P-179 Automated Cartridge Remover for radioactive solid waste handling in radiopharmaceutical production
Gary Perkins, ANSTO

P-183 Optimization of the Copper Mediated [18F]Radiofluorination (CMRF) of Arylstannane Precursors Using A “Design of Experiments” (DoE) Approach.
Gregory Bowden, Werner Siemens Imaging Center, Department of Preclinical Imaging and Radiopharmacy, Eberhard Karls University Tuebingen

P-187 Fully Automated MPLC-Based Manufacturing Process and Evaluation of Potential Stabilizers for Flortaucipir 18F Injection
Junichi Ogikubo, Avid Radiopharmaceuticals, Inc., a wholly owned subsidiary of Eli Lilly and Company

P-191 Synthesis of [11C]PK11195 and [11C]Ro15-4513 using a Cassette-based Method
Abdul Karim Haji Dheere, King’s College London

P-195 Adaptation and optimization of [18F]Florbetaben ([18F]FBB) radiosynthesis to a microdroplet reactor
Ksenia Lisova, University of California Los Angeles

17:30 POSTER SESSION 1A: MULTIMODALITY IMAGING PROBES / NANOPARTICLES

P-198 Elaboration of nanocarriers based on biocompatible polymers for the specific vectorisation of an imaging agent
Nicolas Lepareur, Centre Eugene Marquis, Dept: Nuclear Medicine

P-201 Highly Stable Near Infrared Dye-Cerasomes for Synergistic Chemo-Photothermal Therapy of Colorectal Cancer
Xu Zhang, Peking University

P-204 Application of 64Cu-Mn-PEG-d-MNP as a multimodal imaging contrast agent in tumor PDX model
Xia Lei, Department of Nuclear Medicine, Peking University Cancer Hospital & Institute

P-207 Peptide modified and radiometals loaded BP quantum dots for targeted PET imaging-guided tumor photothermal and photodynamic therapy
Kuan Hu, National Institute of Radiological Sciences

P-210 Synthesis and Bioevaluation of 64Cu-labeled Multifunctional Gold Nanoparticle Conjugates as Biovehicle for Brain Penetrating
Xia Shao, University of Michigan

P-213 Pharmacokinetics Study of Different Sized Iron Oxide Nanoparticles using Simultaneous PET/MR
Yong Hyun Cho, Seoul National University Hospital

P-216 Functionalised graphene nanoflakes as potential theranostic agents
Jennifer Lamb, University of Zurich

P-219 111In-radiolabeling of tri-PEGylated porous silicon nanoparticles and their in vivo evaluation in murine 4T1 breast cancer model
Dave Lumen, University of Helsinki

17:30 POSTER SESSION 1A: RADIOLABELED COMPOUNDS - ONCOLOGY (IMAGING)

P-270 Radioiodinated hyaluronan for imaging pancreatic stromal remodeling related to pancreatic cancer development
Zhonglin Liu, University of Arizona

P-275 Monitoring the response of PD-L1 expression to EGFR-TKIs in NSCLC xenografts by immuno-PET imaging
Dan Li, Tongji Medical College, Huazhong University of Science and Technology

P-280 New, potent PSMA-inhibitors using squaric acid for coupling and increased affinity
Lukas Greifenstein, Johannes Gutenberg University Mainz, Institute of Nuclear Chemistry

P-285 18F-Radiolabeling and Preliminary Preclinical Evaluation of a HSP90 ligand
Patrik Nordeman, Uppsala University Hospital

P-290 A novel 99mTc-labeled molecular probe for PD-L1 detection
Xiaoping Xu, Fudan University Shanghai Cancer Center

P-295 Site-specifically radiolabelled Human PD-L1 Nanobody: a new tool for clinical PET imaging
Jessica Bridoux, In Vivo Cellular and Molecular Imaging (ICMI), Vrije Universiteit Brussel (VUB)

P-300 Screening His-tagged Nanobodies by 99mTc(CO)3(H2O)3-Radiolabeling and SPECT/CT for Her2-positive Cancer Molecular Imaging in vivo
Mingwei Wang, Fudan University Shanghai Cancer Center

P-305 Preparation, Evaluation and SPECT/CT imaging of 99mTc-radiolabeled Nanobody for Her2-positive breast cancer
Mingwei Wang, Fudan University Shanghai Cancer Center

P-315 Direct-labeling of Iron Oxide Nanoparticles with 89Zr and its Biological Application in Targeting of Cancer Cells
Pyeong Seok Choi, Korea Atomic Energy Research Institute

P-320 Imaging features and prognosis of peripheral primitive neuroectodermal tumors with 18F-FDG PET/CT imaging
Xiaobo Niu, First Affiliated Hospital of Zhengzhou University

P-325 A 89Zr Labeled Star-PEG Polymer as a Radiotracer for Image-Guide Drug Delivery
Denis Beckford-Vera, University of California, San Francisco

P-330 [18F]Triacoxib: A novel radiotracer for PET imaging of COX-2 identified through in situ click chemistry.
Marcus Litchfield, University of Alberta

P-335 Radiosynthesis, in vitro and in vivo evaluation of [18F]Fluorphenylglutamine and [18F]Fluorbiphenylglutamine as novel ASCT-2 directed tumor tracers.
Tristan Baguet, Ghent University

17:30 POSTER SESSION 1A: RADIOLABELED COMPOUNDS - ONCOLOGY (THERAPY & THERANOSTICS)

P-338 CD146-targeted, Multimodal Image-guided Photoimmunotherapy of Melanoma
Weijun Wei, Shanghai Jiao Tong University Affiliated Sixth People's Hospital

P-341 [89Zr]ZrDFO-CR011 PET Imaging to Predict Response to an Antibody Drug Conjugate for gpNMB in Triple Negative Breast Cancer
Supum Lee, Yale School of Medicine

P-344 Evans blue attachment prolongs blood half-life and improves radionuclide therapy in a patient-derived xenograft model of pancreatic neuroendocrine tumors
Liang Zhao, The First Affiliated Hospital of Xiamen University

P-347 PET imaging with [11C]NMS-E973 reveals difference between healthy and malignant expressed HSP90
Koen Vermeulen, KU Leuven

P-350 Preclinical evaluation of chemokine receptor 4 (CXCR4) as a theranostic target in high-risk neuroblastoma
Dijie Liu, University of Iowa

P-353 Optimization of 177Lu-labeled GRPR-antagonist PEG2-RM26 for GRPR-targeted radiotherapy: influence of chelator on labeling, stability and biodistribution
Bogdan Mitran, Uppsala University

P-356 [64Cu]CuCl2 PET metallomics for determining the anticancer mechanism of novel drug Dextran-Catechin
Giancarlo Pascali, ANSTO

P-359 177Lu-PSMA-I＆T PSMA Radioligand Therapy in Metastatic Castration-Resistant Prostate Cancer: First Clinical Trial in Asia
Ting Bu, Nanjing Medical University

17:30 POSTER SESSION 1A: RADIOPHARMACOLOGY

P-381 Radioiodinated 4-(p-iodophenyl)butyric acid as a versatile agent for in vivo Imaging with SPECT
Xuejun Wen, Xiamen University

P-383 Evaluation of potential cleavable linkers for reduction of renal accumulation of radiolabeled peptides and antibody fragments using mouse renal brush border membranes
Frederik Cleeren, Radiopharmaceutical Research, Department of Pharmacy and Pharmacology, University of Leuven

P-385 Structure-based design of a new CXCR4 targeting peptidomimetic molecule for potential PET imaging
Mohammadreza Kamali Sarvestani, German Cancer Research Center (DKFZ)

P-387 Evaluation of Bivalent Peptides as Radioligands for Peptide Receptor Radionuclide Therapy of Prostate Cancer
Nina Romantini, Paul Scherrer Institute

17:30 POSTER SESSION 1A: TARGETRY

P-389 Preliminary evaluation of the enriched 68Zn chloride solution target for the continuous production of 68Ga chloride on a medical cyclotron
Karin Michaelsen Nielsen, Center for Nuclear Technologies, Technical Univeristy of Denmark

P-393 Automated production of 68Ga chloride and 68Ga-Dotatate on a low energy medical cyclotron.
William Tieu, Molecular Imaging and Therapeutic Research Unit, South Australian Health and Research Institute

P-395 First experience on producing 68Ga with liquid target at HUS Medical Imaging Center using a Cyclone KIUBE 180 cyclotron
Teija Koivula, HUS Helsinki University Hospital, Medical Imaging Center, Cyclotron Unit

P-398 Chromatographic Separation Methods for Nuclear Medicine Radioisotopes
Daniel McAlister, Eichrom Technologies, LLC

P-399 Initial Results of Cyclotron Produced 68Ga and their Post-processing Using Solid Targets.
Dirk Mueller, Zentralklinik Bad Berka GmbH

18:15 POSTER SESSION 1B: RADIOCHEMISTRY - 18F

P-002 Radiosynthesis of a novel 18F-labeled triazole PET tracer for imaging GluN2B in the brain
Steven Liang, MGH/Harvard

P-007 Synthesis and application of [18F]fluorobenziodoxole
Miguel Cortes Gonzalez, Stockholm University

P-012 Cobalt-Catalyzed C–F Bond Borylation of Aryl Fluorides for PET Applications
Eunsung Lee, POSTECH

P-017 An Improved Synthesis of 4-(4-[18F]fluorophenyl)piracetam, a PET Agent for Parkinson’s Disease
Murthy Akula, University of Tennessee Medcial center

P-022 Rapid and Chemoselective Ligation of Hydroxylamine-functionalized Biomolecules with [18F]6-Fluoronicotinoyltrifluoroborate at Room Temperature
Hazem Ahmed, ETH Zurich

P-027 Development of a new 18F-labeled radioligand for imaging sigma2 receptors by positron emission tomography
Friedrich-Alexander Ludwig, Helmholtz-Zentrum Dresden-Rossendorf, Institute for Radiopharmaceutical Cancer Research, Department of Neuroradiopharmaceuticals, Research Site Leipzig

P-032 Site-specific conjugation and 18F radiolabeling of non-immunoglobulin-based scaffold proteins
Mathilde Vandamme, KU Leuven

P-037 Synthesis and In-Vitro Evaluation of Novel PET Probes 18F-CNPI and 18F-CNBI for Glycogen Synthase Kinase-3 Imaging
Mukesh Pandey, Mayo Clinic, Department of Radiology

P-042 BTC5A (Bis-Triethylene glycol-functionalized Crown-5-calix[4]Arene) analogs: Phase-transfer catalysts for Aromatic [18F]fluorination
Wonchang Lee, Department of Transdisciplinary studies, Graduate School of Convergence Science and Technology, Seoul National University

P-047 Bis-triethylene Glycolic Crown-5-Calix[4]arene as an Efficient Phase-transfer Catalyst for Nucleophilic Radiofluorination with K18F
Chan Ho Park, Inha University

P-052 Preparation of 18F-labeled aromatic amino acids by copper-mediated radiofluorination
Johannes Ermert, Forschungszentrum Jülich GmbH, Institute of Neuroscience and Medicine, INM-5, Nuclear Chemistry

P-057 INVESTIGATION OF THE METABOLIC STABILITY OF NEW SILICON-BASED FLUORIDE ACCEPTOR 18F-TRACERS
Sofia Otaru, University of Helsinki, Department of Chemistry

P-062 A new method for synthesis of 18F-FDG: using integrated flow board with micro reactor
Wansheng Liang, Department of Nuclear Medicine, No. 940 Hospital of the Joint Logistic Support Force

P-067 A Novel PET Probe for In Vivo Imaging of Free Radical Species
David Dick, University of Iowa

P-072 Improved Synthesis and Quality Control of [18F]PSMA-1007
Antje Fasel, ABX advanced biochemical compounds

P-077 Experimental study on the diagnosis of hepatocellular carcinoma by 18F-NOTA-NSC-GLU PET/CT
Xianhong Xiang, The First Affiliated Hospital of Sun Yat-Sen University 

18:15 POSTER SESSION 1B: RADIOCHEMISTRY - OTHER RADIONUCLIDES

P-154 In vivo imaging of diesel exhaust particulates in mice via efficient radioactive iodine labeling of polycyclic aromatic hydrocarbon assemblies
Jongho Jeon, Korea Atomic Energy Research Institute

P-156 Radioiodinated EIPBA for PR targeting with enhanced nucleus uptake via phenylboronic acid conjugation
Fei Gao, Xiamen University

P-158 TLR5 as a target for Flavopiridol effect on breast cancer in mice model
Dai Shi, Shangdong University

18:15 POSTER SESSION 1B: AUTOMATION / MICROFLUIDICS / PROCESS DEVELOPMENT

P-164 Radio-analytical RP-HPLC methods for synthesis monitoring and quality control of [18F]FET
Min Wang, Indiana University School of Medicine

P-168 Towards continuous cyclotron production of PET radiometals: membrane-based liquid-liquid extraction in flow of 68Ga, 64Cu, 89Zr, and 45Ti
Kristina Pedersen, Center for Nuclear Technologies, Technical University of Denmark

P-172 Automated radiosynthesis of [177Lu]Lu-PSMA-617 on the iPHASE MultiSyn module
Christian Wichmann, Olivia Newton-John Cancer Research Institute

P-176 Simple and fully automatic production of (S)-[18F]28 using all-in-one chemistry module
Sang Ju Lee, Asan Medical Center

P-180 First in Southeast Asia (Singapore) clinical study utilizing an automated synthesis of [11C] Metomidate on Tracerlab Fx C Pro in compliance with PIC/S GMP
Xin Jie Wee , Clinical Imaging Research Center

P-184 Radiochemical and analytical aspects of inter-institutional quality control measurements on radiopharmaceuticals
Erik de Blois, Erasmus MC

P-188 Improved Florbetapir 18F Injection Manufacturing Process
Wei Zhang, Avid Radiopharmaceuticals, Inc., a wholly owned subsidiary of Eli Lilly and Company

P-192 Use of a novel high-throughput microdroplet reaction platform for rapid optimization of [18F]fallypride synthesis conditions.
Alejandra Rios, UCLA

P-196 Optimization of Reagents for Automated Isolation of 211At from Irradiated Bismuth Targets Using Tellurium-Packed Columns
Yawen Li, University of Washington

18:15 POSTER SESSION 1B: MULTIMODALITY IMAGING PROBES / NANOPARTICLES

P-199 Dynamic PET imaging of tetrahedral DNA nanoparticles enables quantitative evaluation of kidney function via mathematical modeling
Dawei Jiang, University of Wisconsin - Madison

P-202 In situ Conversion of Rose Bengal Microbubble into Nanoparticle for Enhanced Antitumor Efficacy of Sonodynamic Therapy
Rui Hou, Peking University Health Science Center

P-205 Development and preclinical evaluation of intrinsically radiolabeled [103Pd]AuPd nanoparticles in an injectable seed-forming system for nanobrachytherapy
Matthias Fach, DTU Nanotech

P-208 Design and synthesis of an Optical-PET bimodal imaging probe based on a NIR fluorophore and 18F
Simon Specklin, Imagerie Moléculaire In Vivo UMR1023 CEA, INSERM, CNRS, Université Paris Sud, Université Paris-Saclay, Service Hospitalier Frédéric Joliot

P-211 Polyphenols-Doped Liquid Metal Nanodroplets for Multimodal imaging
Junjie Yan, Jiangsu Institute of Nuclear Medicine

P-214 Chelator “Free” 64Cu-Radiolabeled Carbon Nitride 2D Nanodots for PET Imaging
Chul Hee Kim, Inha University

P-217 Regioselective Labeling of Biovectors with a Novel Dual-modality Fluorescence/Nuclear Imaging Probe
Kuo-Ting Chen, Erasmus MC, Department of Radiology & Nuclear Medicine

P-220 64Cu-Radiolabeled Polymeric Micellar Nanoparticles for Targeting EGFR in Cancer
Melinda Wuest, University of Alberta

18:15 POSTER SESSION 1B: RADIOLABELED COMPOUNDS - NEURO SCIENCES

P-231 Validation of [11C]UCB-J as a PET tracer for imaging of synaptic vesicle glycoprotein 2A in the Q175DN mouse model of Huntington’s disease
Klaudia Cybulska, University of Antwerp

P-235 Evaluation of the brain bio-distribution of [11C]BIIB104, an AMPA positive allosteric modulator in the living NHP brain using positron emission tomography
Sangram Nag, Karolinska Institute

P-238 Synthesis and evaluation of a new PET ligand for imaging of monoacylglycerol lipase in brain.
Wakana Mori, Department of Radiopharmaceuticals development, National Institute of Radiological Sciences, National Institutes for Quantum and Radiological Science and Technology

P-243 Progress towards the first adenosine A1R full agonist PET radioligand
Min Guo, National Institutes of Health/National Institute on Alcohol Abuse and Alcoholism

P-247 Preclinical evaluation in rats and non-human primates of [18F]GE387, a novel 18 kDa translocator protein (TSPO) PET radioligand with low binding sensitivity to human polymorphism rs6971.
Matthew Hird, University of Cambridge

P-251 A novel 18F-labeled D4-receptor ligand
Michael Willmann, INM-5

P-255 Automated Synthesis and Separation of 18F-JNJ-1070, a PET tracer for AMPA-TARPγ8 receptors
Chaofeng Huang, Janssen Research and Development

18:15 POSTER SESSION 1B: RADIOLABELED COMPOUNDS - ONCOLOGY (IMAGING)

P-259 A novel dual integrin αvβ3 and tumor necrosis factor receptor–targeting PET/CT radiotracer
Zijun Chen, Xiamen University

P-263 Transport into the central nervous system of [18F]FLT and [18F]Fludarabine for brain tumors
Fabienne Gourand, CYCERON ISTCT/LDM-TEP

P-269 C-C Chemokine Receptor Type 2 (CCR2) Targeted PET Imaging in Genetically-engineered Pancreatic Cancer Mouse Model
Xiaohui Zhang, Washington University in St. Louis

P-274 A Pretargeted Imaging Strategy for Immune Checkpoint Ligand PD-L1 Expression in Tumor Based on Bioorthogonal Diels-Alder Click Chemistry
Lin Qiu, Fudan University

P-279 The prognostic value of 18F-FDG PET/CT textural features in patients with primary gastric diffuse large B cell lymphoma (PG-DLBCL)
Yi Zhou, West China Hospital of Sichuan University

P-284 Multimodality hypoxia imaging using Positron Emission Tomography (PET) and Multispectral Optoacoustic Tomography (MSOT): A Comparative Study.
Edward Robins, Singapore Bioimaging Consortium

P-289 PET Molecular Targets and Near-Infrared Fluorescence Imaging of Liver Tumor-Initiating Cells
Xiaoyi Guo, Peking University

P-294 EGFR-TK imaging by 99mTc labeled complex bearing a quinazoline pharmacophore
Zhan Si, Fudan University

P-299 11C labeled methotrexate derivatives for tumor imaging
Xia Shao, University of Michigan

P-304 68Ga-labeled Non-blocking nanobody for targeting PET imaging of tumor PD-L1 expression
Gaochao Lv, Jiangsu Institute of Nuclear Medicine

P-309 Caspase-3 activity-based PET probes for assessment of early response to cancer therapy
Filipe Elvas, University of Antwerp

P-314 A novel 68Ga labeled peptide conjugate for potential use in imaging of HER2-positive breast cancer
Feng Gao, Department of Medical Imaging, Jinling Hospital

P-319 18F labeling of an anti-HER2 sdAb with 6-fluoronicotinyl moiety via the inverse electron-demand Diels-Alder reaction (IEDDAR) including a renal brush border enzyme-cleavable linker
Zhengyuan Zhou, Duke University Medical Center

P-324 11C labeled BLZ945 as PET tracer for Colony Stimulating Factor 1 Receptor imaging in the brain
Berend van der Wildt, Stanford University

P-329 Development of a 89Zr-labelled anti-EGFR and cMET bispecific antibody for PET imaging of triple-negative breast cancer
Alessandra Cavaliere, Department of Radiology and Biomedical Imaging, Yale University

P-334 Evaluation of tryptophan derivative, [18F]trifluoromethyl-L-tryptophan ([18F]CF3-L-Trp) as PET/MR agent for detection of prostate cancer: Comparison with L-[11C]Methionine ([11C]MET)
Ho Young Kim, Seoul National University

18:15 POSTER SESSION 1B: RADIOLABELED COMPOUNDS - OTHER MEDICAL DISCIPLINES

P-361 Development of a PET tracer targeting neutrophil elastase for inflammation imaging
Patrik Nordeman, Uppsala University Hospital

P-364 18F-Radiolabeling and in vivo evaluation of two diverse glycomimetics using PET
Klas Bratteby, University of Copenhagen

P-367 Synthesis and characterization of 9-(4-fluoro-3-(hydroxymethyl)butyl)-2-(phenylthio)-6-oxopurine ([18F]FHBT) as a PET tracer for HSV1-tk reporter gene imaging
Takeshi Fuchigami, Nagasaki University

P-370 Synthesis of 68Ga-NOTA-Insulin a PET Probe for Insulin Imaging
Mukesh Pandey, Mayo Clinic, Department of Radiology

P-373 Synthesis and initial preclinical evaluation of the CRTH2 antagonist [11C]MK-7246
Jonas Eriksson, Uppsala University Hospital and Department of Medicinal Chemistry, Uppsala University

P-376 Evaluation of [18F]NEBIFQUINIDE, a new TSPO PET tracer, in a mouse model of non-alcoholic fatty liver disease
Neydher Berroteran-Infante, Department of Biomedical Imaging and Image-guided Therapy, Division of Nuclear Medicine, Medical University of Vienna

P-379 Optimization of 89Zr-based radiotracers for long-term in vivo cell tracking with PET imaging
Ida Jonsson, Karolinska Institutet, Department of Clinical Neuroscience

18:15 POSTER SESSION 1B: MISCELLANEOUS

P-405 HILIC - A simple HPLC method to determine [18F]fluoride in plasma and tissue samples
Barbara Wenzel, Helmholtz-Zentrum Dresden-Rossendorf

P-408 Albendazole ameliorates triple-negative breast cancer by inhibiting glucose uptake pathway
HongLian Liu, Soochow University

P-411 Study of the radioactive contaminants appearing during [18F]FDG production
Pal Mikecz, Kaposi Mór Teaching Hospital, Medicopus Nonprofit Ltd.

P-414 Use of [11C]CO2 to study Molecular Organic Frameworks adsorption performance
Giancarlo Pascali, ANSTO

P-417 Validation of [18F]PSMA-1007 - Does synthesis platform matter?
Tom Christian Adamsen, Haukeland University Hospital