Tuesday, May 28 ISRS 2019 Program Schedule

08:30    KEYNOTE LECTURE 3

            Session Chairs: Julie Sutcliffe

O-23       Catalyzing the development and use of radiopharmaceuticals with total-body PET
Simon Cherry, UC Davis

09:15    WILEY AWARD SESSION

            Session Chairs: Michael Kassiou | Chrysoula Vraka

O-24       11C-Trifluoromethylation of Primary Aromatic Amines with [11C]CuCF3 via Diazonium Salts Generated In Situ
Nicholas Young, National Institute of Mental Health

O-25       A Long-Acting Radiolabeled RGD Analogue 177Lu-AB-3PRGD2 for Targeted Radiotherapy of Tumor
Hannan Gao, Peking University

O-26       Development of a radiation detector for miniaturized analysis of radiopharmaceutical samples via microchip electrophoresis
Jason Jones, UCLA

O-27       Develop a peptide-based PET radiotracer for imaging PD-L1 expression in cancer
Kuan Hu, National Institute of Radiological Sciences

10:15    COFFEE BREAK 1, 5/28

11:00    RADIOCHEMISTRY - 11C AND OTHER POSITRON EMITTERS

            Session Chairs: Alex Poot | Ming-Rong Zhang

O-28       In-loop carbonylation-a novel and simplified method for 11C labeling of drugs and radioligands
Melodie Ferrat, Karolinska Institut

O-29       Palladium/Copper-Mediated Rapid 11C-Cyanation of (Hetero)arylstannanes
Zhouen Zhang, RIKEN Center for Biosystems Dynamics Research

O-30       Rapid, One-Pot Radiosynthesis of [carbonyl-11C]Formamides from Primary Amines and [11C]CO2.
Federico Luzi, King's College London

O-31       Radiosynthesis of 11C labeled acylsulfonamides using [11C]CO carbonylation chemistry
Berend van der Wildt, Stanford University

O-32       Synthesis of radiolabeled [11C]formamides: A 11C labeled building block to access novel PET tracers
Coralie Bonnemaire, UMC Amsterdam

O-33       Rapid and efficient BEMP-mediated synthesis of 11C-labelled benzimidazolones using [11C]carbon dioxide
Kaisa Horkka, Karolinska Institut

12:30    LUNCH 5/28

14:00    RADIOLABELED COMPOUNDS - OTHER MEDICAL DISCIPLINES & RADIOPHARMACOLOGY AND CARDIOLOGY

            Session Chairs: Gunnar Antoni | Xing Yang

O-34       [11C]Metoclopramide as a PET tracer to visualize ABCB1 induction at the mouse blood-brain-barrier
Severin Mairinger, Preclinical Molecular Imaging - AIT Austrian Institute of Technology GmbH

O-35       A novel high-throughput cassette microdosing approach to screen PET imaging agents
Mingyue Sun, College of Chemistry, Beijing Normal University

O-36       Synthesis and in vivo Evaluation of a Novel 18F-Labelled PET Tracer 18F-BBR for Myocardial Perfusion Imaging in Mice
Xiaoai Wu, Sichuan University

O-37       Exclusive kidney accumulation of DNA origami nanostructures protects kidneys from acute injury
Dawei Jiang, University of Wisconsin - Madison

15:45    RAPID FIRE POSTER 2

P-159     Direct nucleophilic radioiodination and astatination of antibodies via pre-conjugated arylboronic acids
Francois Guérard, Université de Nantes, CRCINA, Nuclear Oncology Group

P-389     Preliminary evaluation of the enriched 68Zn chloride solution target for the continuous production of 68Ga chloride on a medical cyclotron
Karin Michaelsen Nielsen, Center for Nuclear Technologies, Technical Univeristy of Denmark

P-022     Rapid and Chemoselective Ligation of Hydroxylamine-functionalized Biomolecules with [18F]6-Fluoronicotinoyltrifluoroborate at Room Temperature
Hazem Ahmed, ETH Zurich

P-274     A Pretargeted Imaging Strategy for Immune Checkpoint Ligand PD-L1 Expression in Tumor Based on Bioorthogonal Diels-Alder Click Chemistry
Lin Qiu, Fudan University

P-241     Characterization of the rotenone mouse model of Parkinson’s disease using radioligands for the adenosine A2A receptor ([18F]FESCH) and the nicotinic α4β2 receptor ((-)-[18F]Flubatine)
Thu Hang Lai, Helmholtz-Zentrum Dresden-Rossendorf

P-027     Development of a new 18F-labeled radioligand for imaging sigma2 receptors by positron emission tomography
Friedrich-Alexander Ludwig, Helmholtz-Zentrum Dresden-Rossendorf, Institute for Radiopharmaceutical Cancer Research, Department of Neuroradiopharmaceuticals, Research Site Leipzig

P-297     68Ga and MMAF dual-labelled single-chain variable fragments (scFv) for PET imaging of HER2 overexpressed tumors
Ruisi FU, Imperial College London

P-245     A novel imaging probe with selectivity for tau-oligomeric protein aggregates: In vitro evaluation and radiolabelling with 18F
Stephen Thompson, University of Cambridge

P-382     Evaluation of [18F]DBT10 as potential α7 nAChRs diagnostic biomarker for PET imaging of stroke-associated neuroinflammation in a sheep stroke model
Rodrigo Teodoro, Helmholtz-Zentrum Dresden-Rossendorf, Institute of Radiopharmaceutical Cancer Research

P-302     A 99mTc-labeled cyclic peptide for integrin αvβ6-targeted SPECT/CT imaging of tumor and pulmonary fibrosis in preclinical mouse models
Xun Feng, Peking University

P-249     Developing PET Ligands targeting CNS Stem Cells for Application in Multiple Sclerosis Imaging
Steven Kealey, University of Cambridge

P-029     Ligand effect in the radiofluorination of aryl pinacol boronates catalyzed by copper (II) triflate complexes
Dmitrii Antuganov, Almazov National Medical Research Centre

16:00    RADIOLABELED COMPOUNDS - ONCOLOGY (IMAGING) SESSION 2

            Session Chairs: Yun-Sang Lee | Steven Liang

O-38       Development of the first 18F-labeled MCT1/MCT4 lactate transport inhibitor: Radiosynthesis and preliminary in vivo evaluation in mice
Masoud Sadeghzadeh, Helmholtz-Zentrum Dresden-Rossendorf

O-39       Preclinical Evaluation of 99mTc-Labeled Anti-EpCAM Nanobody Conjugates for Imaging EpCAM Receptor Expression by Immuno-SPECT
Tianyu Liu, Medical Isotopes Research Center and Department of Radiation Medicine, Peking University

O-40       PET imaging of human melanoma using a novel 18F-labeled dual AmBF3 derivative of alpha-melanocyte stimulating hormone
Chengcheng Zhang, BC Cancer Research Centre

O-41       Imaging of In Vivo Tumor Senescence with a Novel Beta-Galactosidase Specific PET Tracer
Jonathan Cotton, Werner Siemens Imaging Center, Department of Preclinical Imaging and Radiopharmacy, Eberhard Karls University

O-42       The in vivo and in vitro validation of two activing-receptor like kinase 5 targeting PET tracers
Lonneke Rotteveel, Amsterdam UMC, VU University, Radiology and Nuclear medicine, Radionuclide Center, De Boelelaan 1085c, Amsterdam, The

O-43       Molecular imaging of autotaxin: Targeting the crossroad of inflammation and cancer.
Marcus Litchfield, University of Alberta

17:30    POSTER SESSION 2A: RADIOCHEMISTRY - 18F

P-003     Synthesis and evaluation of trialkyammonium salts as 18F labeling precursors for AZD4694 (NAV4694)
Hui Xiong, Avid Radiopharmaceuticals, Inc., a wholly-owned subsidiary of Eli Lilly and Company

P-008     Synthesis of 6-[18F]Fluoropyridine-3-carbaldehyde-O-[4-(2,5-dioxo-2,5-dihydropyrrol-1-yl)butyl and pentyl]oximes, Novel Thiol Reactive Bifunctional Agents for Peptide Labeling.
Murthy Akula, University of Tennessee Medcial center

P-013     18F-fluorination of BaGdF5 nanoparticles for multimodal imaging and PET/CT biodistribution in mouse.
Laura Fernandez-Maza, Universidad de Sevilla. CSIC. Junta de Andalucía

P-018     A novel [18F]fluoride relay reagent for radiofluorination reactions
Bo Zhang, Australia's Nuclear Science and Technology Organisation (ANSTO)

P-023     BF3-Gln-C2 as a stable 18F-labeled glutamine derivative for imaging tumor
Zhibo Liu, Peking University

P-028     Investigation of [18F]FESCH for PET imaging of the adenosine A2A receptor in a rotenone-based mouse model of Parkinson´s disease and development of a two-step one-pot radiolabeling strategy
Susann Schroeder, Helmholtz-Zentrum Dresden Rossendorf

P-033     Development of new fluorination methods for 18F labelling of aromatic compounds
Rémi Pelletier, Imagerie Moléculaire In Vivo UMR1023 CEA, INSERM, CNRS, Université Paris Sud, Université Paris-Saclay, Service Hospitalier Frédéric Joliot

P-038     Radiofluorination of higher-valent aryliodines: A comparative investigation of [18F]fluoroarenes produced from hypervalent compounds a different oxidation states
Young-Do Kwon, Yonsei University College of Medicine

P-043     Rhenium Complexation-Dissociation Strategy for 18F Labelling of Bidentate PET Ligands
Mitchell Klenner, ANSTO

P-048     Organophosphine Fluoride Acceptors Based One-Step 18F-Labeling in Aqueous Media
Huawei Hong, Xiamen University

P-053     The use of methanolic solution of tetrabutylammonium tosylate in the preparation of reactive [18F]fluoride and aliphatic radiofluorinations
Dmitrii Antuganov, Almazov National Medical Research Centre

P-058     Radiosynthesis of [18F]mFBG on Trasis All-in-One for PET imaging in children with neuroendrocrine malignancies
Emilie Da Costa Branquinho, Institut Curie, Department of Radiopharmacology

P-063     Cu-Mediated Aminoquinoline-Directed Radiofluorination of Aromatic C-H Bonds with K18F
So Jeong Lee, University of Michigan

P-068     Using novel radiofluorination methodologies to advance the development and translation of 18F-labeled PET tracers: The Yale Experience
Zhengxin Cai, PET Center, Department of Radiology and Biomedical Imaging, Yale University School of Medicine

P-073     Two-step 18F-labeling of Pept-ins™ targeting S. aureus via [18F]F-py-TFP
Kaat Luyten, Radiopharmaceutical Research, Department of Pharmaceutical and Pharmacological Sciences, KU Leuven

17:30    POSTER SESSION 2A: RADIOCHEMISTRY - 11C AND OTHER POSITRON EMITTERS

P-079     Base effect on the radiosynthesis of P2X7R radioligands [11C]GSK1482160 and its halo-analogs
Qi-Huang Zheng, Indiana University School of Medicine

P-082     An original radio-biomimetic synthesis of 11C-nor-buprenorphine for PET imaging
Fabien Caillé, Imagerie Moléculaire In Vivo UMR1023 CEA, INSERM, CNRS, Université Paris Sud, Université Paris-Saclay, Service Hospitalier Frédéric Joliot

P-085     CuI-mediated 11C-cyanation of (hetero)aromatic bromide and synthesis of [11C]perampanel
Hideki Ishii, Department of Radiopharmaceuticals Development National Institute of Radiological Sciences National Institutes for Quantum and Radiological Science and Technology

P-088     Rhodium-Catalyzed Addition of Organozinc Iodides to [11C]Isocyanates
Benjamin Rotstein, University of Ottawa & University of Ottawa Heart Institute

P-091     Rapid One-step 11C Carboxylation of Terminal Alkynes using [11C]CO2.
Francesca Goudou, King's College London

P-094     Challenge of [11C]pirenzepine radiosynthesis: structure analysis of a novel rearrangement product
Verena Pichler, Medical University of Vienna

P-097     A [11C]CO dispensing system for fast and efficient screening of 11C carbonylation reactions
Berend van der Wildt, Stanford University

P-100     A facile method for the preparation of [11C]cyanide from [11C]methyl iodide
Tatsuya Kikuchi, National Institute for Quantum and Radiological Science and Technology

17:30    POSTER SESSION 2A: RADIOLABELED COMPOUNDS - NEURO SCIENCES

P-229     Improved Synthesis of 18F MK6240, A PET Tracer for Neurofibrillary Tangles
Meixiang Yu, Houston Methodist Hospital Research Institute

P-233     PET Radiotracer Translation from Rats to Higher Species, Using an Increased-throughput in vivo Evaluation Strategy
Elina Tampio L'Estrade, University of Copenhagen

P-237     Assessment of adenosine agonist to improve drug delivery via the nasal to brain route of administration
Shivashankar Khanapur, Singapore Bio-imaging Consortium, A Star

P-241     Characterization of the rotenone mouse model of Parkinson’s disease using radioligands for the adenosine A2A receptor ([18F]FESCH) and the nicotinic α4β2 receptor ((-)-[18F]Flubatine)
Thu Hang Lai, Helmholtz-Zentrum Dresden-Rossendorf

P-245     A novel imaging probe with selectivity for tau-oligomeric protein aggregates: In vitro evaluation and radiolabelling with 18F
Stephen Thompson, University of Cambridge

P-249     Developing PET Ligands targeting CNS Stem Cells for Application in Multiple Sclerosis Imaging
Steven Kealey, University of Cambridge

P-253     Quantitative Structure-Property Relationship Coupled with PET Imaging Predicts Blood-Brain-Barrier Transport of Benzamides
Sung Won Kim, National Institute on Alcohol Abuse and Alcoholism / Nat. Institutes of Health

17:30    POSTER SESSION 2A: RADIOLABELED COMPOUNDS - ONCOLOGY (IMAGING)

P-257     PET Imaging of Human Melanoma Using 68Ga-DOTA-GGNle-CycMSHhex: Bench to Bedside Translation
Yubin Miao, University of Colorado Denver

P-261     Construction of Molecular Probe 68Ga-DOTA-VAP and Micro PET/CT Imaging Study in GRP78 Overexpressing Tumor
Haitao Zhao, Department of Nuclear Medicine, Renji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai 200127, China

P-265     [64Cu]Cu-NOTA- and [64Cu]Cu-NODAGA-6Ahx-RM2 GRPR-peptide antagonists for the targeting of prostate cancer
Antonio Shegani, University Of Missouri Research Reactor Center (MURR)

P-267     Performance of a new preclinical PET/CT system for quantitative total-body dynamic imaging with low tracer doses
Sebastian Eigner, Bruker

P-272     Nivolumab-DTPA as Platform for PD-1 Expression Probe for Precise Diagnosis of Colon Cancer
Danni Li, Changhai Hospital of Shanghai

P-277     Synthesis and radiolabeling of a novel glutamine derivative: (2S,4S)4-[18F]FEBGln
Yong Huang, Beijing Institute of Brain Disorders, Capital Medical University

P-282     Discovery of [18F]JK-PSMA-7 as PET-probe suitable for imaging of small PSMA expressing lesions
Boris Zlatopolskiy, Institute of Radiochemistry and Experimental Molecular Imaging (IREMB), University Hospital of Cologne

P-287     Synthesis and evaluation of radiogallium labeled ADAM8-activatable cell penetrating peptides for diagnosis of pancreatic cancer
Ryota Yamaguchi, Nagasaki University

P-292     Biotin modified red blood cell membrane based nanoparticles: biomimetic nano-platform for avoiding immune barriers of in vivo system
Jun Young Lee, Korea Atomic Energy Research Institute

P-297     68Ga and MMAF dual-labelled single-chain variable fragments (scFv) for PET imaging of HER2 overexpressed tumors
Ruisi Fu, Imperial College London

P-302     A 99mTc-labeled cyclic peptide for integrin αvβ6-targeted SPECT/CT imaging of tumor and pulmonary fibrosis in preclinical mouse models
Xun Feng, Peking University

P-307     Optimizing the molecular design of 68Ga-labeled affibody molecules for in vivo PET imaging of HER3 expression
Sara Rinne, Uppsala University

P-312     Targeting Experimental Study in Nude Mice Bearing Insulinoma with GLP-1 Receptor Agonist Exendin-4 Radiolabelled with Radionuclide 99mTc and 68Ga
Li Gui Ping, Nanfang Hospital, Southern Medical University

P-317     Preparation of 68Ga-Labeled Carbonic Anhydrase IX (CAIX) Ligands via CBT/1,2-Aminothiol Click Reaction for Tumor Hypoxia Imaging
Kuo-Ting Chen, Erasmus MC, Department of Radiology & Nuclear Medicine

P-322     18F labeling of a single domain antibody fragment with 2,5-dioxopyrrolidin-1-yl 3-(1-(2-(2-(2-(2-[18F]fluoroethoxy)ethoxy)ethoxy)ethyl)-1H-1,2,3-triazol-4-yl)-5-(guanidinomethyl)benzoate, an alternative residualizing prosthetic agent.
Ganesan Vaidyanathan, Duke University Medical Center

P-327     Imaging Hypoxia-Driven Regulation of Nucleoside and Amino Acid Transporters in Breast Cancer
Daniel Krys, University of Alberta/ Department of Oncology

P-332     Synthesis and in vivo evaluation of metabolic radiotracers (S) and (R) 4-[18F]fluoro-3-hydroxybutyrate
Frank Wuest, University of Alberta

P-418     Synthesis and Evaluation of [18F]SuPAR for PET Imaging of DNA Damage-dependent PARP Activity
Bin Shen, Stanford University

17:30    POSTER SESSION 2A: RADIOPHARMACOLOGY

P-380     Synthesis and radiopharmacological evaluation of three 18F-labeled celecoxib derivatives – a quest to trick metabolism
Markus Laube, Helmholtz-Zentrum Dresden-Rossendorf, Institute of Radiopharmaceutical Cancer Research, Dresden, Germany

P-382     Evaluation of [18F]DBT10 as potential α7 nAChRs diagnostic biomarker for PET imaging of stroke-associated neuroinflammation in a sheep stroke model
Rodrigo Teodoro, Helmholtz-Zentrum Dresden-Rossendorf, Institute of Radiopharmaceutical Cancer Research

P-384     Structure-based design of novel squaric acid coupled KuE targeting vectors with PSMA and first in vitro evaluation studies
Hanane Lahnif, Johannes Gutenberg - University Mainz Institute of Nuclear Chemistry

P-386     Bioequivalence study of 68Ga radiolabeling DOTA-iNGR kit
Shuailiang Wang, Fourth Military Medical University

17:30    POSTER SESSION 2A: TARGETRY

P-390     Radiochemical separation / purification for establishing a 44Ti/44Sc generator
Sandrine Huclier, Subatech and Arronax

P-392     Production and application therapeutic radionuclides at TRIUMF: Auger emitters
Valery Radchenko, TRIUMF

P-396     Automated production of 64Cu, 89Zr, 68Ga, 45Ti, 123I and 124I with a medical cyclotron, using a commercial solid target system
Mario Malinconico, COMECER S.p.A., Castel Bolognese, ITALY

P-400     Evaluation of cyclotron produced 43,44,47Sc from titanium(0) and titanium oxide
Christopher Loveless, University of Alabama at Birmingham

P-402     47Sc separation by extraction chromatography using TBP resin
Renata Mikolajczak, National Centre for Nuclear Research Radioisotope Centre POLATOM

18:15    POSTER SESSION 2B: RADIOCHEMISTRY - 18F

P-004     Simplified synthesis of [18F]NS12137 via copper-mediated 18F-fluorination
Salla Lahdenpohja, Turku PET Centre, University of Turku

P-009     Synthesis and Biological Investigation of A Novel 18F-Labeled Benzoimidazotriazine: A Potential Radioligand for In Vivo Phosphodiesterase 2A (PDE2A) PET imaging
Rodrigo Teodoro, Helmholtz-Zentrum Dresden-Rossendorf, Institute of Radiopharmaceutical Cancer Research

P-014     4-Nitrophenyl activated esters are superior synthons for indirect radiolabelling of biomolecules; A direct radiofluorination tolerance and acylation kinetics study
Mohammad Haskali, Peter MacCallum Cancer Centre

P-019     An improved method for preparing [18F]AV-45 using solid-phase extraction purification
Lifang Zhang, College of Chemistry, Beijing Normal University

P-024     One-step synthesis of [18F]MC225 intended for GMP compliant productions.
Philip Elsinga, University Medical Center Groningen

P-029     Ligand effect in the radiofluorination of aryl pinacol boronates catalyzed by copper (II) triflate complexes
Dmitrii Antuganov, Almazov National Medical Research Centre

P-034     Improved and simpler radiosynthesis of [18F]ADAM, a radioligand for PET imaging of serotonin transporters
Selena Milicevic Sephton, University of Cambridge

P-039     One-step synthesis of [18F]fluoro-4-(vinylsulfonyl)benzene (FVSB): a thiol reactive synthon for selective radiofluorination of peptides and proteins
Jennifer Murphy, University of California Los Angeles

P-044     Drying free 18F labeling of phosphate analogues with high stability in vivo
Hongzhang Yang, Xiamen University Center for Molecular Imaging and Translational Medicine

P-049     Discovery of new ligand for copper mediated [18F]trifluoromethylation from aryl iodides
Ji Young Choi, Seoul National University

P-054     18F-Fluorination on natural monophosphate
Zhaobiao Mou, Xiamen University

P-059     2-[18F]Fluoro-5-iodopyridine ([18F]FIPy): a novel reactive prosthetic group for the fast site specific radiolabeling via Pd-catalyzed cross coupling reactions
Mohamed Aymen Omrane, Forschungszentrum Jülich GmbH, Institute of Neuroscience and Medicine,

P-064     RADIOFLUORINATION OF PYRIDINYL IODONIUM SALTS FOR THE PREPARATION OF 3/5-[18F] FLUOROPYRIDINES : OPTIMIZATION, MECHANISM INVESTIGATION AND SCOPE
Cecile Perrio, Cyceron

P-069     Arabinofuranose-derived PET radiotracers for sensing gram-negative bacteria in vivo
David Wilson, University of California, San Francisco

P-074     An open-label, single arm trial to explore potential imaging biomarkers correlate with efficacy of bevacizumab combined with conventional therapy in newly diagnosed glioblastoma
Li Li, Shandong Cancer Hospital

18:15    POSTER SESSION 2B: RADIOCHEMISTRY - 11C AND OTHER POSITRON EMITTERS

P-080     Preclinical evaluation of [11C]AZ13713945 and its analogs as muscarinic acetylcholine receptor M4 PET ligands
Steven Liang, MGH/Harvard

P-083     Pd catalyzed cross-coupling of [11C]MeLi and its application in the synthesis and evaluation of a potential PET tracer for the vesicular acetylcholine transporter (VAChT)
Hugo Helbert, UMC Groningen

P-086     Synthesis and radiopharmacological evaluation of a 11C-labeled azadipeptide nitrile inhibitor for targeting cysteine cathepsins
Markus Laube, Helmholtz-Zentrum Dresden-Rossendorf, Institute of Radiopharmaceutical Cancer Research, Dresden, Germany

P-089     Facile Radiosyntheses of [11C]Tetrazoles and [11C]Triazines from (Hetero)Arylborons
Zhouen Zhang, RIKEN Center for Biosystems Dynamics Research

P-092     Synthesis of [11C]nicotinamide analogs for imaging of nicotinamide N‑methyltransferase activity
Toshimitsu Okamura, National Institute of Radiological Sciences, National Institutes for Quantum and Radiological Science and Technology

P-095     Application of New Positron Imaging Agent 68Ga-pentixafor PET/CT in Primary Aldosteronism
Jie Ding, Peking Union Medical College Hospital

P-098     Novel 11C Radiolabelling of Pt, Pd and Ru Complexes using [11C]CS2: Towards Applications in PET
Philip Miller, Imperial College London

P-101     Facilitated troubleshooting in (+)-[11C]PHNO synthesis by investigation of reagents, byproducts and intermediates
Verena Pichler, Medical University of Vienna

18:15    POSTER SESSION 2B: AUTOMATION / MICROFLUIDICS / PROCESS DEVELOPMENT

P-162     A concentration method for efficient microscale one-pot radiosynthesis of [18F]FET and [18F]fallypride
Ren Iwata, Tohoku University

P-166     Automated radiosynthesis of (2S,4R)-4-[18F]fluoroglutamine for clinical application
Yan Zhang, College of Chemistry, Beijing Normal University

P-170     “In-loop” 18F-fluorination: A proof-of-concept study
Kenneth Dahl, Azrieli Centre for Neuro-Radiochemistry, Research Imaging Centre, Centre for Addiction and Mental Health

P-174     Automated radiosynthesis of O-(2-[18F]fluorothyl)-O-(4-nitrophenyl)methylphosphonate: a PET tracer surrogate of VX
Thomas Hayes, University of California San Francisco

P-178     Automated handling of 11C waste gases
Gary Perkins, ANSTO

P-182     Using a microdroplet reactor for rapid, nucleophilic synthesis of [18F]FDOPA
Jia Wang, UCLA

P-186     Large scale continuous-flow production of [18F]DCFPyl on a microfluidic synthesis module
Alex Poot, Amsterdam UMC, VU University

P-190     New self-cleaning module for implementing process development and automation in 18F-radiochemistry
Nicolas Maindron, ORA

P-194     Radiosynthesis in microliter droplets at the 10s of GBq scale – impact of starting activity on reaction performance
Philip Chao, UCLA

18:15    POSTER SESSION 2B: RADIOLABELED COMPOUNDS - CARDIOLOGY

P-222     Radiosynthesis of b-phenylethylamine derivatives for cardiac sympathetic nervous PET imaging
Yulin He, Affiliated Hospital of Inner Mongolia Medical University

P-224     18F-Py-(cApoPep)2: Apoptosis-targeting 18F-labeled PET tracer for imaging of the vulnerable plaque
Byoung Se Lee, FutureChem

P-226     Synthesis and biological evaluation of fluorescence- and 68Ga-labeled anti-miR-21
Eike Janssen, Hannover Medical School

P-228     Detecting Vulnerable Atherosclerotic Plaques by 68Ga-Labeled Divalent Cystine Knot Peptide
Lei Jiang, Shanghai Pulmonary Hospital, Tongji University School of Medicine

18:15    POSTER SESSION 2B: RADIOLABELED COMPOUNDS - NEURO SCIENCES

P-230     Radiosynthesis and in vitro characterization of an 125I labeled radiotracer for α-synuclein
Zhude Tu, Washington University School of Medicine in Saint Louis, Department of Rdiology

P-234     Synthesis and characterization of a difluoroboron complex of 18F labeled curcumin derivative for β-amyloid plaque imaging
Hyunjung Kim, Department of Health Sciences and Technology, SAIHST, Sungkyunkwan University

P-239     Radiosynthesis and evaluation of a negative allosteric modulator for the PET imaging of metabotropic glutamate receptor 2 in rat brain
Ming-Rong Zhang, Department of Radiopharmaceutics Development, National Institute of Radiological Sciences, National Institutes for Quantum and Radiological Science and Technology

P-242     Evaluation of Fluorinated Benzazepine and Benzo[7]annulen-7-amine Analogues for Development as Imaging Agents for the GluN2B Subunits of the N-Methyl-D-Aspartate Receptor
Ahmed Haider, ETH Zurich

P-246     SPECT imaging of the glymphatic pathway with 111In-labeled ovalbumin in the rat brain
Vladimir Shalgunov, Department of Drug Design and Pharmacology, University of Copenhagen

P-250     18F-labeled Azine Derivatives as Potential Aβ imaging Agent for Diagnosis of Alzheimer’s Disease
Kaixiang Zhou, Beijing Normal University

P-254     18F-Labeled Styrylquinoxaline Derivatives as Tau Probe for PET
Longfei Zhang, Beijing Normal University

18:15    POSTER SESSION 2B: RADIOLABELED COMPOUNDS - ONCOLOGY (IMAGING)

P-258     Preparation and Evaluation of [18F]AlF-NOTA-NOC for PET Imaging of Neuroendocrine Tumors
Johan Dam, Odense Universitetshospital

P-262     Pretargeting of experimental prostate cancer using complementary L-oligonucleotides: radiochemical and radiopharmacological characterization
Sandy Weissflog, Helmholtz-Zentrum Dresden-Rossendorf, Institute of Radiopharmaceutical Cancer Research, Department of Radionuclide Theragnostics

P-266     Stable Site-Specific Labeling of Nanobodies with 99mTc for SPECT Imaging
Tianyu Liu, Medical Isotopes Research Center and Department of Radiation Medicine, Peking University

P-268     Preclinical evaluation of [18F]CETO as a tool for the study of the adrenals
Mahabuba Jahan, Uppsala University Hospital, PET-Centre, Uppsala, Sweden

P-273     Development of 99mTc-Labeled Trivalent Isonitrile Radiotracer for Folate Receptor Targeted Imaging
Nadeem Ahmed Lodhi, Seoul National University, College of Medicine

P-278     64Cu-labeled gold nanoclusters for PET imaging in lung cancer model
Weiwei Han, Institute of High Energy Physics

P-283     Imaging-Guided Anti-PD-L1 Immunotherapy with SPECT/CT of 99mTc-Labeled Nanobody
Yue Wu, Medical Isotopes Research Center and Department of Radiation Medicine, Peking University

P-288     Evaluation of Targeting and Distribution Pattern of Trastuzumab Biosimilar Using Radioiodine Labeling Method
Joo Hyun Kang, Korea Institute of Radiological and Medical Sciences

P-293     [55Co]Co-DOTATATE improves PET imaging contrast of somatostatin receptor expressing tumours: Comparison with [64Cu]Cu-DOTATATE and [68Ga]Ga-DOTATATE
Helge Thisgaard, Department of Nuclear Medicine, Odense University Hospital

P-298     18F pretargeted PET imaging of cetuximab antibody via in vivo sydnone-alkyne click reaction
Mylène Richard, Imagerie Moléculaire In Vivo UMR1023 CEA, INSERM, CNRS, Université Paris Sud, Université Paris-Saclay, Service Hospitalier Frédéric Joliot

P-303     Comparison of [18F]DMFB and [18F]DMPY2 for PET imaging of melanoma
Ayoung Pyo, Chonnam National University Medical School

P-308     Synthesis and evaluation of a 99mTc-labelled glucose derivative for tumor imaging
Xuran Zhang, Beijing Normal University

P-313     Synthesis and biological evaluation of a furin-activatable molecular probe for PET imaging of breast cancer
Ling Qiu, Jiangsu Institute of Nuclear Medicine

P-318     Pre-Clinical evaluation of a Novel [18F]-labeled d-TCO amide derivative for Bioorthogonal Pretargeted Imaging of Cancer
Eduardo Ruivo, University of Antwerp

P-323     The value of 18F-FDG PET/CT in the diagnosis of multiple myeloma
Xiaobo Niu, First Affiliated Hospital of Zhengzhou University

P-328     Mild and site-specific labeling of peptides using a novel biarsenical imaging probe
Mikhail Kondrashov, Karolinska Institut

P-333     In vivo evaluation of [11C]osimertinib for PET imaging of tumours expressing mutated EGFR
Antonia Högnäsbacka, Amsterdam UMC, VU University

18:15    POSTER SESSION 2B: RADIOLABELED COMPOUNDS - OTHER MEDICAL DISCIPLINES

P-363     Investigation of the potentials of a thymidine phosphorylase imaging probe for the differential diagnosis of nonalcoholic steatohepatitis
Kei Higashikawa, Hokkaido University

P-366     Visualisation of fibrosis after tissue damage with PET – A tracer for the fibroblast activation protein
Laura Langer, Hannover Medical School

P-369     Development and preclinical evaluation of an immunoPET tracer for clinical imaging of Aspergillosis
Andreas Maurer, Werner Siemens Imaging Center, Deptartment of Preclinical Imaging and Radiopharmacy, Eberhard Karls University Tuebingen

P-372     A novel monoacylglycerol lipase-targeted 18F-labeled probe for positron emission tomography imaging of brown adipose tissue in the energy network
Ran Cheng, School of Medical Imaging, Tianjin Medical University

P-375     Development of a new method for the microbiological analysis of Iodine 131
Abdelmjid Aiboud, National Energy Center of Nuclear Science and Technology - Morocco

P-378     Targeting bacterial peptidoglycan with 11C-D-Alanine and 11C-D-Alanyl-D-Alanine
Matthew Parker, University of California, San Francisco

18:15    POSTER SESSION 2B: TARGETRY

P-388     Separation study of silver radionuclides from a palladium target irradiated by cyclotron
Tomoyuki Ohya, National Institutes for Quantum and Radiological Science and Technology (QST), National Institute of Radiological Sciences (NIRS)

P-391     Cyclotron production of 47Ca for 47Ca/47Sc generator
Rafał Walczak, Institute of Nuclear Chemistry and Technology

P-394     Production, Quality Control of next-generation PET Nuclide 89Zr
Feng Wang, Peking University Cancer Hospital & Institute

P-397     Shortage of 68Ge / 68Ga Generators - Incoming Material Inspection and GMP Compliant Use of Non-approved Generators
Dirk Mueller, Zentralklinik Bad Berka GmbH

P-401     Isolation of 99mTc from the gamma irradiated 100Mo target
Magdalena Gumiela, Institue of Nuclear Chemistry and Technology

P-403     Cyclotron production of 44Sc from enriched 44Ca targets
Wioletta Wojdowska, National Centre for Nuclear researc Radioisotopecentre POLATOM