Thursday, May 30 ISRS 2019 Program Schedule
08:30 KEYNOTE LECTURE 5
Session Chairs: Robert Mach
O-55 Development of Radiopharmaceutical; From Bench to FDA Approved Clinical Application
Hank Kung, University of Pennsylvania
09:15 AUTOMATION / MICROFLUIDICS / PROCESS DEVELOPMENT
Session Chairs: Salvatore Bongarzone | Giancarlo Pascali
O-56 High-throughput radio-TLC using Cerenkov luminescence imaging
Jia Wang, UCLA
O-57 Rapid, inexpensive and high-yielding radiosynthesis of 68Ga-PSMA using a versatile microfluidic device for prostate cancer PET imaging
Xin Zhang, Vanderbilt University
O-58 Automated radiosynthesis of [18F]atorvastatin via Ru-mediated 18F-deoxyfluorination: a prospective PET imaging tool for the assessment of statin related mechanisms of action
Goncalo Clemente, University Medical Center Groningen
O-59 Online positron detector for LC/MS/MS
Anna Kirjavainen, Turku PET Center, University of Turku
10:15 COFFEE BREAK 1, 5/30
11:00 RADIOLABELED COMPOUNDS - NEURO SCIENCES SESSION 2
Session Chairs: Klaus Kopka | Robert Mach
O-60 Radiosynthetic Optimization of the SV2A Radiotracer 18F-SDM-8: A Search for the Best Precursor
Xiaoai Wu, Sichuan University
O-61 Discovery and First-in-Human Evaluation of M4 PAM PET Tracer [11C]MK-6884
Wenping Li, Merck Research Laboratories
O-62 An 18F-Labeled Radiotracer for PET Imaging of 11β-HSD1: From Chemistry Development to Clinical Study
Songye Li, Yale PET Center, Department of Radiology and Biomedical Imaging, Yale University School of Medicine
O-63 Structure-Activity Relationship Studies of Pyridine-Based Ligands and Identification of a Fluorinated Derivative for the PET Imaging of Cannabinoid Type 2 Receptors
Linjing Mu, ETH Zurich
O-64 Synthesis and evaluation of 18F-labeled benzimidazopyridine derivatives as novel PET tracers for tau imaging
Hiroyuki Watanabe, Graduate School of Pharmaceutical Sciences, Kyoto University
O-65 Development of a 11C PET Pro-Radiotracer for Imaging the Astroglial Excitatory Amino Acid Transporter 2
Igor Fontana, King's College London
12:30 LUNCH 5/30
13:00 SRS MEMBER MEETING
14:00 RADIOLABELED COMPOUNDS - ONCOLOGY (IMAGING) SESSION 3
Session Chairs: Jason Lewis | Zhaofei Liu
O-66 Comparison of Al18F and 68Ga-labeled NOTA-PEG4-LLP2A for PET imaging of very late antigen-4 in melanoma
Yongkang Gai, Department of Nuclear Medicine, Wuhan Union Hospital, Tongji Medical College, Huazhong University of Science and Technology
O-67 18F-labelled click based PSMA-tracer for prostate cancer imaging
Verena Bohmer, University Medical Center Groningen
O-68 Preclinical evaluation of [18F]DiFA, a novel hypoxia PET probe, in a rat intracranial glioma model
Hironobu Yasui, Graduate School of Veterinary Medicine, Hokkaido University
O-69 Dynamic PET/CT imaging of 18F-(2S, 4R)4-fluoroglutamine in breast cancer patients
Xiaoxia Xu, Peking University Cancer Hospital and Institute
15:00 COFFEE BREAK 2, 5/30
15:45 RAPID FIRE POSTER 3
P-400 Evaluation of cyclotron produced 43,44,47Sc from titanium(0) and titanium oxide
Christopher Loveless, University of Alabama at Birmingham
P-194 Radiosynthesis in microliter droplets at the 10s of GBq scale – impact of starting activity on reaction performance
Philip Chao, UCLA
P-283 Imaging-Guided Anti-PD-L1 Immunotherapy with SPECT/CT of 99mTc-Labeled Nanobody
Yue Wu, Medical Isotopes Research Center and Department of Radiation Medicine, Peking University
P-089 Facile Radiosyntheses of [11C]Tetrazoles and [11C]Triazines from (Hetero)Arylborons
Zhouen Zhang, RIKEN Center for Biosystems Dynamics Research
P-363 Investigation of the potentials of a thymidine phosphorylase imaging probe for the differential diagnosis of nonalcoholic steatohepatitis
Kei Higashikawa, Hokkaido University
P-206 Novel highly water-soluble and spherical boron nitride nanoparticles for boron neutron capture therapy
Liping Li, Shanxi Medical University
P-333 In vivo evaluation of [11C]osimertinib for PET imaging of tumours expressing mutated EGFR
Antonia Högnäsbacka, Amsterdam UMC, VU University
P-083 Pd catalyzed cross-coupling of [11C]MeLi and its application in the synthesis and evaluation of a potential PET tracer for the vesicular acetylcholine transporter (VAChT)
Hugo Helbert, UMC Groningen
P-185 iMiLAB: A New Cassette-based Micro-fluidic Platform for PET Radiotracer Synthesis – Initial Results for the Synthesis of [11C]Methionine
Francesca Goudou, King's College London
P-096 A “Universal” Method for Rapid 11C-Radiolabeling of PSMA Targeted Ligands via [11C]CO2 Fixation
Joseph Downey, King's College London
P-252 First-in-human evaluation of 18F-LY2459989, the first 18F-labeled PET radiotracer for imaging of the kappa opioid receptor
Songye Li, Yale PET Center, Department of Radiology and Biomedical Imaging, Yale University School of Medicine
P-296 Sultone-based radiochemistry for the development of 18F-radiotracers for high performance hypoxia PET imaging
Cecile Perrio, Cyceron
16:00 RADIOLABELED COMPOUNDS - ONCOLOGY (THERAPY & THERANOSTICS)
Session Chairs: Hank Kung | Caterina Ramogida
O-70 Dual Radionuclide Theranostic Pretargeting
Outi Keinanen, Hunter College
O-71 [68Ga]/[177Lu]P17-087: a potential theranostic agent targeting PSMA expressing tumor
Seok Rye Choi, Five Eleven Pharma
O-72 Selection of the optimal macrocyclic chelators for labelling with 111In and 68Ga improves contrast of HER2 imaging using engineered scaffold protein ADAPT6
Vladimir Tolmachev, Uppsala University
O-73 A Metabolically Stable Boron-Derived Tyrosine Serves as A Theranostic Agent for Positron Emission Tomography Guided Boron Neutron Capture Therapy
Zhibo Liu, Peking University
O-74 Barium ferrite magnetic nanoparticles labeled with 223Ra: a new potential magnetic radiobioconjugate for targeted alpha therapy
Aleksander Bilewicz, Instutute of Nuclear Chemistry and Technology
O-75 Photodynamic therapy with a CD276-targeted agent for enhancing tumor anti-PD-1/PD-L1 immune checkpoint inhibition
Bao Rui, Medical Isotopes Research Center and Department of Radiation Medicine, School of Basic Medical Sciences, Peking University Health Science Center
17:30 POSTER SESSION 3A: RADIOCHEMISTRY - 18F
P-005 Development, biological evaluation and PET application of [18F]fluoro-glyco”RGD”
Sandrine Lamande-Langle, Université de Lorraine
P-010 A simple SPE purification method for 18F-radiolabeling: Proof-of-concept study in stilbene amyloid-β ligands with a neopentyl labeling group
Tetsuro Tago, Tokyo Metropolitan Institute of Gerontology
P-015 Automated radiosynthesis of a PDE10A PET radiotracer: [18F]TZ20A - two-pot, two-step, and two-HPLC purification on one module
Jinda Fan, UAB
P-020 18F Labeled Pyrrolopyrimidine Derivatives Targeting LRRK2 for evaluation of Parkinson’s Disease
Xueyuan Chen, Xiamen University
P-025 Development of scandium-catalyzed N-[18F]fluoroalkylation of aryl and heteroaryl amines with [18F]epifluorohydrin
Masayuki Fujinaga, Department of Radiopharmaceuticals Development, National Institute of Radiological Sciences, National Institutes for Quantum and Radiological Science and Technology
P-030 Elution efficiency of [18F]fluoride from OASIS WAX cartridge using DMA solution of 4-dimethylaminopyridinium trifluoromethanesulfonate
Dmitrii Antuganov, Almazov National Medical Research Centre
P-035 New strategy for infection PET imaging by 18F labeling of a bacterial azide-containing LPS
Simon Specklin, Imagerie Moléculaire In Vivo UMR1023 CEA, INSERM, CNRS, Université Paris Sud, Université Paris-Saclay, Service Hospitalier Frédéric Joliot
P-040 Radiofluorination of p-aminobenzoic acid for bacterial infection imaging with PET
Jianyang Fang, State Key Laboratory of Molecular Vaccinology and Molecular Diagnostics & Center for Molecular Imaging and Translational Medicine
P-045 Studies on F2-free UV photon-mediated production of [18F]F2
Anna Krzyczmonik, University of Turku
P-050 Convenient access to 18F-labeled amines through the Staudinger reduction
Vladimir Shalgunov, Department of Drug Design and Pharmacology, University of Copenhagen
P-055 Explorations towards the chemical scope of [18F]triflyl fluoride, a new gaseous [18F]fluoride source
Lizeth Haveman, VU University Medical Center
P-060 [18F/19F] isotopic exchange radiolabeling of pentafluorosulfanyl groups
Hugh Hiscocks, University of Technology Sydney
P-065 Aryltrialkylstannanes are viable substrates for [18F]trifluoromethylation
Bo Yeun Yang, Brigham and Women's Hospital
P-070 Preclinical evaluation of [18F] Tetrafluoroborate ([18F] TFB) radiopharmaceutical, using a semi automatically method.
Juan C Manrique-Arias, Universidad Nacional Autónoma de México (UNAM)
P-075 High-Purity Synthesis of [18F]-AlF-pHLIP® Using Semi-Preparative HPLC
Stephen Carlin, Memorial Sloan Kettering Cancer Center
17:30 POSTER SESSION 3A: RADIOCHEMISTRY - RADIOMETALS
P-103 Preparation and quality control of ready for injection [64Cu]copper dichloride solution for theranostic applications
Miguel Avila-Rodriguez, Universidad Nacional Autonoma de Mexico (UNAM)
P-106 A one-pot synthesis of DOTA-hydrazide via HATU-mediated coupling reaction for biomacromolecule radiolabeling
Mirkka Sarparanta, University of Helsinki
P-109 PET-Imaging of PD-L1 expression for immunotherapy monitoring
Sven Stadlbauer, German Cancer Research Center
P-112 Synthesis of estrogen derivatized cyclopentadienyl complexes of technetium and rhenium with potential radiopharmaceutical application
Maria Tejeria, Chemistry University
P-115 [68Ga]Ga-HBED-CC-DiAsp: a new renal function imaging agent
Shengyu Shi, Collage of Chemistry, Beijing Normal University
P-118 A novel method for radiolabeling monoclonal antibodies under mild conditions with the therapy nuclide 177Lu using AAZTA5-en-Squaric acid as chelator-conjugate
Euy Sung Moon, Johannes Gutenberg University Mainz, Institute of Nuclear Chemistry
P-121 The first Curie-quantity production of [68Ga]Ga-PSMA-HBED-CC
Katie Gagnon, GE Healthcare
P-124 Novel radiochemical isolation strategy for the production of no-carrier-added 133mBa
Eduardo Aluicio-Sarduy, University of Wisconsin-Madison
P-127 H4picoopa: an acyclic high-denticity chelator for targeted alpha therapy.
Luke Wharton, University of British Columbia Department of Chemistry
P-130 Technetium complexes of 2-hydrazinopyridine and hydrazinonicotinamide (HYNIC)-conjugated peptides. Insights from LC-MS and electrophoresis studies.
Justyna Pijarowska-Kruszyna, National Center for Nuclear Research, Radioisotope Centre POLATOM
P-133 New phosphonic acids as components of bone seeking radiopharmaceuticals
Galina Tsebrikova, Frumkin Institute of Physical Chemistry and Electrochemistry, Russian Academy of Sciences
P-136 Synthesis of a photoactivatable aryl-azide-SAAC ligand and in vivo studies with the photochemically conjugated [99mTc][Tc(CO)3(SAAC-azepin)]-MetMAb
Florian Gribi, University of Zurich
P-139 Simultaneous photochemical conjugation and 89Zr-radiolabelling of antibodies for immuno-PET
Simon Klingler, University of Zurich
P-142 Development of Bifunctional N2O2 Schiff Base Ligands for Re(III) and Tc(III) Radiopharmaceuticals
Jakob Baumeister, University of Missouri
P-145 HOPO: A potential chelator for use in 44Sc and 47Sc based theranostic agents
Michael Phipps, Graduate Center of the City University of New York
P-148 161Tb Purification by High Performance Ion Chromatography (HPIC) from Irradiated 160Gd
Andrew Burgoyne, Belgian Nuclear Research Centre (SCK•CEN), Institute for Nuclear Materials Science
P-151 An optimised manual 64Cu-radiolabelling and purification method of [64Cu]CuSAR-bisPSMA; reformulation and radiostability for prospective automation and preclinical development.
Lawson Spare, Clarity Pharmaceuticals
17:30 POSTER SESSION 3A: MULTIMODALITY IMAGING PROBES / NANOPARTICLES
P-197 Development of platforms as dyes for combined [18F]PET/NIRF imaging
Sandrine Lamande-Langle, Université de Lorraine
P-200 Characterization of TCP-1 multimodality imaging probes in targeting colorectal cancer cells
Zhonglin Liu, University of Arizona
P-203 Development of bimodal (PET/NIR) tumor tracers for non-invasive staging and fluorescence guided surgery of prostate cancer
Carsten Kramer, German Cancer Research Center (dkfz)
P-206 Novel highly water-soluble and spherical boron nitride nanoparticles for boron neutron capture therapy
Liping Li, Shanxi Medical University
P-209 Improving signal-to-noise ratio of hypoxia positron emission tomography (PET) imaging via polymeric delivery of [18F]fluoromisonidazole ([18F]FMISO)
Jeroen Goos, Memorial Sloan Kettering Cancer Center
P-212 99mTc/Gd- and PEG/FA-Functionalized ultrasmall nanographene oxides for SPECT/MR imaging of cancers
Mingwei Wang, Fudan Univerisity Shanghai Cancer Center
P-215 Radiolabeling of SUV size liposome with hexadecyl-4-[18F]fluorobenzoate ([18F]HFB) for tumor imaging
Sun Hak Lee, Neuroscience Research Institute, Gachon University
P-218 The diagnostic efficiency of Bombesin functionalized superparamagnetic iron oxide nanoparticles in in breast cancer mouse models
Li Li, Shandong Cancer Hospital
P-221 Radioiodine Labelled Melanin Nanoparticles for Cancer Brachytherapy
Xinyu Wang, Jiangsu institute of Nuclear Medicine
17:30 POSTER SESSION 3A: RADIOLABELED COMPOUNDS - ONCOLOGY (THERAPY & THERANOSTICS)
P-339 A Novel Tracer for GD2-Positive Neuroblastoma
Sarah Spreckelmeyer, Charité Berlin - Nuclear Medicine Department - Radiopharmacy
P-342 Theranostics of Glioma Mice with a novel agent 111In-DOTA-AEK22
Yu Tang, Sichuan University
P-345 PARaDIM – A PHITS-based Monte Carlo tool for internal dosimetry
Lukas Carter, Memorial Sloan Kettering Cancer Center
P-348 Second Generation of Triazolominigastrins: Towards Further Improvement of Tumour-Targeting Characteristics of Radiopeptidomimetics
Nathalie Grob, ETH Zurich
P-351 Monitoring therapeutic response of lung adenocarcinoma to ZHER2:V2-pemetrexed by SPECT imaging with 99mTc-ZHER2:V2-pemetrexed.
Jingya Han, The Fourth Hospital of Hebei Medical University
P-354 [68Ga]Ga-ABY-025/PET-CT for individualized management of breast cancer patients: automated production for multicenter clinical study
Irina Velikyan, Department of Medicinal Chemistry, Uppsala University
P-357 Safety and Response of An Evans Blue-modified 177Lu-labeled Octreotate in Treatment of Metastatic Neuroendocrine Tumors: A Prospective Pilot Study
Qingxing Liu, Peking Union Medical College Hospital
P-360 Experimental study of 68Ga/177Lu-PSMA I&T: a novel PSMA inhibitor for theranostic of prostate cancer
Lulu Zhang, Nanjing Medical University Affiliated Nanjing First Hospital
17:30 POSTER SESSION 3A: RADIOLABELED COMPOUNDS - OTHER MEDICAL DISCIPLINES
P-362 Novel imaging of the third gasotransmitter hydrogen sulfide using 99mTc-labeled polyhydroxy acids
Jae Min Jeong, Seoul National University Hosp
P-365 Imaging of occult bacterial infection using 68Ga-Yersiniabactin targeting siderophore transport
Chuangyan Zhai, Southern Medical University
P-368 First-in-class bicyclic peptide based imaging agent targeting for non-invasive diagnosis and monitoring of fibrosis
Irina Velikyan, Department of Medicinal Chemistry, Uppsala University
P-371 Early prediction of radiation induced lung fibrosis using 64Cu-labeled 1,4,7-triazacyclononane,1-glutaric acid-4,7 acetic acid(NODAGA)-galactose-bombesin analogue
Yong Jin Lee, Korea Institute of Radiological &Medicals Sciences
P-374 Research on the preparation of 99mTc-TPN towards VPAC1 receptor and testing in animals
Tao Jiang, Southwest Hospital
P-377 Ex vivo-loaded chylomicron-like particles labelled with 18F-BDP-triglyceride as an imaging agent for brown adipose tissue
Matthias Bauwens, MUMC
17:30 POSTER SESSION 3A: MISCELLANEOUS
P-404 Pre- and Post-intervention air quality monitoring in a low-income radiopharmacy
Hendrikus Boersma, UMCG
P-407 Radiopharmaceutical Production Technology at the Nuclear Medicine Centre Federal Siberian Research Clinical Centre, Russia
Anastasia Ozerskaya, Federal Siberian Research Clinical Centre, FMBA of Russia
P-410 Measurement of the metal impurity in PET probe using the HPLC post-column method
Masayuki Hanyu, National Institute of Radiological Sciences (NIRS), National Institutes for Quantum and Radiological Science and Technology (QST)
P-413 Simultaneous analysis of seven potentially toxic chemical impurities in the radiopharmaceuticals formulations by capillary electrophoresis
Dmitrii Antuganov, Almazov National Medical Research Centre
P-416 A simple spot test for semi-quantitative determination of tetrabutylammonium in [18F] PSMA-1007
Nils Halvorsen, Center for nucl.med/PET, Haukeland University Hospital
18:15 POSTER SESSION 3B: RADIOCHEMISTRY - 11C AND OTHER POSITRON EMITTERS
P-078 Development of a novel PET ligand for imaging leucine rich repeat kinase 2
Steven Liang, MGH/Harvard
P-081 Immuno-PET imaging with 89Zr-Atezolizumab in Low and High PD-L1 Expressing Renal Cell Carcinoma Patient-Derived Xenograft Models
Guiyang Hao, UT Southwestern Medical Center
P-084 A mild method to activate molecular sieve 13X for [11C]carbon dioxide entrapment and release
Shuiyu Lu, National Institutes of Health
P-087 New trends in cross-coupling 11C-methylation
Francois Liger, CNRS - CERMEP
P-090 Expanding the Scope of 11C Labelled Ureas: A Universal Method to Access Short-Lived Click Reagents for in vivo PET Imaging
Salvatore Bongarzone, King's College London
P-093 Novel 11C-labeled and 18F-labeled allosteric modulators for M4 imaging
Steven Liang, MGH/Harvard
P-096 A “Universal” Method for Rapid 11C-Radiolabeling of PSMA Targeted Ligands via [11C]CO2 Fixation
Joseph Downey, King's College London
P-099 In-loop synthesis of [11C]D-Methionine
Megan Stewart, University of California, San Francisco
P-102 Some aspects on the specific activity of CH3I
Bruno Nebeling, Synthra GmbH
18:15 POSTER SESSION 3B: RADIOCHEMISTRY - RADIOMETALS
P-105 Copper(II) coordination chemistry of C- and N-alkylated cyclam ligands. Advantage of the triazole unit and application in 64Cu radiochemistry.
Nadia Pellegrini Moïse, Université de Lorraine - L2CM UMR 7053
P-108 Purification of 67Gallium for (pre)clinical application as surrogate for 68Ga
Erik de Blois, Erasmus MC
P-111 Radium-doped BaSO4 Nanoparticles for Future Targeted Alpha Therapy
Falco Reissig, Helmholtz-Zentrum Dresden-Rossendorf
P-114 H5decaox: A High Denticity ‘ox’ Ligand for Diagnostic and Therapeutic Radiometals
Lily Southcott, University of British Columbia Department of Chemistry
P-117 A simple kit-based preparation of [68Ga]Ga-P15-041: a novel bone imaging agent
Haiyan Hong, College of Chemistry, Beijing Normal University
P-120 A novel squaric acid based AAZTA5.SA.KuE conjugate for PET and radiotherapy of prostate cancer: radiolabeling with 68Ga, 44Sc, 64Cu and 177Lu
Tilmann Grus, Johannes Gutenberg University Mainz, Institute of Nuclear Chemistry
P-123 Synthesis of a Glu-urea-Lys based 45Ti-labelled PSMA inhibitor for positron emission tomography
Kristina Pedersen, Center for Nuclear Technologies, Technical University of Denmark
P-126 A small molecule 64Cu-2-phenylethyenesulfonamide (64Cu-PES) as a novel HSP70 targeted imaging agent.
Pradip Ghosh, UT Health Science Center -Houston
P-129 Evaluation of radiation dose on 99Mo absorption of AG1-×8 resin
Jixin Liang, Department of Isotope, China Institute of Atomic Energy
P-132 HPLC for Determination of Unbound 68Ga in Radiopharmaceuticals: Pitfalls and Solutions
Anton Larenkov, State Research Center - Burnasyan Federal Medical Biophysical Center
P-135 Investigations on the mechanism of simultaneous photochemical conjugation and radiolabelling of proteins with modified arylazides
Melanie Gut, University of Zürich - Department of Chemistry
P-138 Effect of Excipients on 68Ga Species Content in Radiopharmaceutical Preparations: Old Biases and New Data
Anton Larenkov, State Research Center - Burnasyan Federal Medical Biophysical Center
P-141 Production and Applications of Radiometal 89Zr
Jeong Hoon Park, Korean Atomic Energy Institute
P-144 Broken symmetry copper complexes of photoactive bis(thiosemicarbazone) ligands for chromophore enhancement of photoradiochemical kinetics
Jose Esteban Flores, University of Zürich
P-147 Refining Theranostic Isotopes of Germanium from Irradiated Cobalt-Gallium Targets
Christopher Kutyreff, University of Wisconsin-Madison, School of Medicine and Public Health, Department of Medical Physics
P-150 Site-specific radiolabeling of antibodies through enzyme-mediated oligosaccharide remodeling
Jiquan Wang, AbbVie
18:15 POSTER SESSION 3B: AUTOMATION / MICROFLUIDICS / PROCESS DEVELOPMENT
P-161 Synthesis and Validation of [18F]6”-Fluromaltotriose, a Radiotracer for Imaging Bacterial Infections
Tom Haywood, Stanford University
P-165 Automated synthesis of 5-[18F]fluoro-α-methyl tryptophan (5-[18F]F-AMT)
Joseph Blecha, UCSF
P-169 Stability of [18F]FE-PE2I
Charlotte Denholt, Department of Nuclear Medicine and PET, Copenhagen University Hospital Rigshospitalet
P-173 Automated Synthesis of [18F]O6-[(4-[18F]fluoro)benzyl]guanine ([18F]pFBG) via [18F]-Fluorobenzyl Alcohol ([18F]4FBnOH) from an Optimized Copper Mediated Radiofluorination (CMRF) of 4-tributyltin-benzyl Alcohol.
Gregory Bowden, Werner Siemens Imaging Center, Department of Preclinical Imaging and Radiopharmacy, Eberhard Karls University Tuebingen
P-177 Automated synthesis of [18F]NAV4694 using GE TracerLab FX-N Pro in compliance with PIC/S GMP
Mohd Fadli Bin Mohammad Noh, Clinical Imaging Research Centre
P-181 Fast HPLC Quality Control (QC) analysis of [18F]MK6240 using a core-shell particle column in partnership with Cerveau Technologies
Fathollah Zakee Bin Fatholmoein, CIRC
P-185 iMiLAB: A New Cassette-based Micro-fluidic Platform for PET Radiotracer Synthesis – Initial Results for the Synthesis of [11C]Methionine
Francesca Goudou, King's College London
P-189 Toward automation of a new process of dry nucleophilic [18F]Fluoride production from [18F]Triflyl fluoride
Nicolas Maindron, ORA
P-193 High-throughput microdroplet radiochemistry platform to accelerate radiotracer development
Jason Jones, UCLA
18:15 POSTER SESSION 3B: RADIOLABELED COMPOUNDS - CARDIOLOGY
P-223 A 18F-PET Probe for Detection of Oxidative Stress in Doxorubicin Induced Cardiotoxicity
Ran Yan, King's College London
P-225 Optimization of the automated synthesis of [11C]mHED - administered and apparent molar activities
Chrysoula Vraka, Department of Biomedical Imaging and Image-guided Therapy, Medical University of Vienna, Division of Nuclear Medicine
P-227 Vulnerable Atherosclerotic Plaques Imaging by VEGFR PET
Zheng Li, Houston Methodist Hospital
18:15 POSTER SESSION 3B: RADIOLABELED COMPOUNDS - NEURO SCIENCES
P-232 Dosimetry and toxicology of [18F]MC225 for measuring P-glycoprotein function at the blood-brain barrier in humans
Jun Toyohara, Tokyo Metropolitan Institute of Gerontology
P-236 Translational development of 18F-FC0324, a PET radiotracer for CB2 receptors imaging
Fabien Caillé, Imagerie Moléculaire In Vivo UMR1023 CEA, INSERM, CNRS, Université Paris Sud, Université Paris-Saclay, Service Hospitalier Frédéric Joliot
P-240 Synthesis and evaluation of tropane-based, radiometal-labeled CNS tracers for the visualization of the dopaminergic transporter system
Sascha Häseli, Institute for Nuclear Chemistry, Johannes Gutenberg-Universität Mainz
P-244 18F radiolabelling and in vitro / in vivo metabolism of [18F]D4-PBR111
Benjamin Fraser, The Australian Nuclear Science and Technology Organisation
P-248 Evaluation of In Vitro and In Vivo Stability to Support the Preclinical and Clinical Development of [11C]MK-6884, a PET Tracer for Imaging M4 Positive Allosteric Modulators
Kerry Riffel, Merck & Co., Inc.
P-252 First-in-human evaluation of 18F-LY2459989, the first 18F-labeled PET radiotracer for imaging of the kappa opioid receptor
Songye Li, Yale PET Center, Department of Radiology and Biomedical Imaging, Yale University School of Medicine
P-256 [18F]FPEB for imaging mGluR5 is a P-gp substrate in the rodent
Kyung Rok Nam, KIRAMS
18:15 POSTER SESSION 3B: RADIOLABELED COMPOUNDS - ONCOLOGY (IMAGING)
P-260 HER2-Targeted Multimodal Imaging of Anaplastic Thyroid Cancer
Weijun Wei, Shanghai Jiao Tong University Affiliated Sixth People's Hospital
P-264 68Ga-labeled GRPR- and VPAC1R-specific peptide heterodimers – a favorable alternative to conventional monospecific peptides for tumor imaging
Simon Lindner, Department of Nuclear Medicine, University Hospital Munich, LMU
P-271 Multi-mode molecular imaging of orthotopic HepG-2 liver hepatocellular carcinoma from animal to clinical: (2S,4R)4-[18F]fluoroglutamine PET holds advantages
Hua Zhu, Peking University Cancer Hospital & Institute
P-276 An Improved Integrin alpha 6-Targeted SPECT Imaging Probe for Tumor Detection
Qi Luo, Institute of Biophysics, CAS
P-281 Synthesis and Evaluation of [18F]Fluoropivalic Acid as PET Imaging Biomarker in HCC
Fui Fong Yong, Singapore Bioimaging Consortium, A*STAR
P-286 Gold nanoclusters integrated with 64Cu for CCR2 positron emission imaging of triple negative breast cancer
Deborah Sultan, Washington University School of Medicine
P-291 11C-labeled Pictilisib as a Novel Molecular Tracer Targeting Phosphatidylinositol 3-kinase for Breast Cancer Imaging
Yongkang Gai, Department of Nuclear Medicine, Wuhan Union Hospital, Tongji Medical College, Huazhong University of Science and Technology
P-296 Sultone-based radiochemistry for the development of 18F-radiotracers for high performance hypoxia PET imaging
Cecile Perrio, Cyceron
P-301 A General cGMP-Compliant Protocol for Facile Synthesis of 18F Labeled FLT and FMISO
Wenchao Qu, Citigroup of Biomedical Imaging Center and Department of Radiology, Weill Cornell Medicine
P-306 Novel 99mTc labelled nitroimidazole xanthates as potential tumor hypoxia imaging agents
Qing Ruan, Beijing Normal University
P-311 Bispecific GRPR-PSMA Radiotracers for Prostate Cancers
Ayman Abouzayed, Uppsala University
P-316 Radiolabelling and preliminary evaluation of 89Zr-DFO-denosumab a novel antibody-based radiopharmaceutical for imaging the receptor activator of the nuclear factor k B ligand (RANKL) in the tumour microenvironment.
Jonatan Dewulf, Antwerp University Hospital
P-321 Synthesis of [89Zr]Zr-DFO-PEG5-Tz and in vivo evaluation of bioorthogonally labeled antibody
Dave Lumen, University of Helsinki
P-326 ImmunoPET imaging of CD146 for orthotopic breast cancer detection
Lei Kang, Peking University First Hospital
P-331 Development of FOXM1 inhibitors as potential theranostic agents: initial steps in the validation of FOXM1 as a positron emission tomography (PET) probe for triple negative-breast cancer detection.
David Perez, University of Alberta
P-336 N-Methyl carboxylic acid substituted glutamate-urea-lysine analogues, more hydrophilic PSMA inhibitors with high binding affinity
Byoung Se Lee, FutureChem
18:15 POSTER SESSION 3B: RADIOLABELED COMPOUNDS - ONCOLOGY (THERAPY & THERANOSTICS)
P-337 131I-AuNPs-TAT Particles Target Cells Nuclei in Colon Cancer for Enhanced Radioisotope Therapy
Weiwei Su, Department of Nuclear Medicine, Changhai Hospital, Navy Medical University
P-340 Synthesis of [211At]MABG Using Remote-controlled Synthesizer and Quality Evaluation
Miho Aoki, Fukushima Medical University
P-343 [58mCo]Co-DOTA-hEGF – a novel ligand for targeted Auger electron therapy of glioblastoma using convection-enhanced delivery.
Vigga Laursen, Department of Nuclear Medicine, Odense University Hospital, Odense, Denmark
P-346 SPECT/CT imaging of chemotherapy-induced tumor apoptosis using 99mTc-labeled dendrimer-entrapped gold nanoparticles
Yan Xing
P-349 Radiolabeling and in vitro evaluation of a TA-MUC1 specific monoclonal antibody and its corresponding single chain fragment with 89Zr, 44Sc and 177Lu: promising tools for diagnosis and therapy of breast cancer
Benedikt Klasen, Institute for Nuclear Chemistry, Johannes Gutenberg-University Mainz, Germany
P-352 Antibody nanotechnology mediated by site-specific assembly enhances antitumor efficacy of therapeutic antibodies via multivalent binding
Ying Zhao, National Center for Nanoscience and Technology
P-355 The study of biodistribution and micro-PET imaging of 18F-BPA in nude mice bearing glioma
Li Fenglin, China Institute of Atomic Energy
P-358 Production and Radiochemical Purity of 177Lu-PSMA-617 for Clinical Trial
Ali Asad, Sir Charles Gairdner Hospital
18:15 POSTER SESSION 3B: MISCELLANEOUS
P-406 Implementation of a Quality Management System: Self-assessments in a Sub Saharan radiopharmacy
Hendrikus Boersma, UMCG
P-409 21 Code of Federal Regulation Part 11, Electronic Records: Electronic Signatures, Scope and Application for the Commercial PET Manufacturing World in the USA
Michael Haka, PETNET Solutions
P-412 Rapid analysis of chemical purity in 68Ga-PSMA-11 and 68Ga-DOTA-NOC by capillary electrophoresis.
Dmitrii Antuganov, Almazov National Medical Research Centre
P-415 Application of BODIPY650/665 for optical imaging of prostate cancer
Sang-Hyun Son, Korea University