Nuclear Medicine and Biology:
Official Journal of the SRS

Nuclear Medicine and Biology publishes original research addressing all aspects of radiopharmaceutical science: synthesis, in vitro and ex vivo studies, in vivo biodistribution by dissection or imaging, radiopharmacology, radiopharmacy, and translational clinical studies of new targeted radiotracers. The importance of the target to an unmet clinical need should be the first consideration. If the synthesis of a new radiopharmaceutical is submitted without in vitro or in vivo data, then the uniqueness of the chemistry must be emphasized.

DECEMBER Issue (Vol. 67) Table of Contents

[18F]F-DPA for the detection of activated microglia in a mouse model of Alzheimer's disease 
Thomas Keller, Francisco R. López-Picón, Anna Krzyczmonik, Sarita Forsback, Anna K. Kirjavainen, Jatta S. Takkinen, Obada Alzghool, Johan Rajander, Simo Teperi, Fanny Cacheux, Annelaure Damont, Frédéric Dollé, Juha O. Rinne, Olof Solin, Merja Haaparanta-Solin 

Automated radiosynthesis of 5-[11C]l-glutamine, an important tracer for glutamine utilization 
Adam J. Rosenberg, Michael L. Nickels, Michael L. Schulte, H. Charles Manning 

Unexpected decrease in in vivo binding of [3H]QNB in the mouse cerebral cortex in the developing brain - A comparison with [11C]NMPB 
Osamu Inoue, Toshiyuki Sato, Kaoru Kobayashi, Antony Gee, Miho Shukuri, Ming-Rong Zhang 

Molar activity – The keystone in 11C-radiochemistry: An explorative study using the gas phase method 
Verena Pichler, Thomas Zenz, Cécile Philippe, Chrysoula Vraka, Neydher Berrotéran-Infante, Sarah Pfaff, Lukas Nics, Marius Ozenil, Oliver Langer, Matthäus Willeit, Tatjana Traub-Weidinger, Rupert Lanzenberger, Markus Mitterhauser, Marcus Hacker, Wolfgang Wadsak 

Efficient cartridge purification for producing high molar activity [18F]fluoro-glycoconjugates via oxime formation 
Outi Keinänen, Denisa Partelová, Osku Alanen, Maxim Antopolsky, Mirkka Sarparanta, Anu J. Airaksinen 

Al[18F]F-complexation of DFH17, a NOTA-conjugated adrenomedullin analog, for PET imaging of pulmonary circulation 
Luis Michel Alonso Martinez, François Harel, Quang T. Nguyen, Myriam Létourneau, Caroline D'Oliviera-Sousa, Bernard Meloche, Vincent Finnerty, Alain Fournier, Jocelyn Dupuis, Jean N. DaSilva 

Tumor uptake and tumor/blood ratios for [89Zr]Zr-DFO-trastuzumab-DM1 on microPET/CT images in NOD/SCID mice with human breast cancer xenografts are directly correlated with HER2 expression and response to trastuzumab-DM1 
Noor Al-saden, Zhongli Cai, Raymond M. Reilly 

Issues in preclinical radiopharmaceutical research: Significance, relevance and reproducibility 
Michael R. Kilbourn, Peter J.H. Scott 

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